ENSMUSG00000044813


Mus musculus
shcellShbregulationdevelopmentdomainproteinbbloodvesselactivitysignaltransductiondifferentiationproliferationsignalingpathwaymembranebindingprenatallethalitydomain-containingadaptershbsuperfamilyangiogenesiskinaseapoptoticprocessmulticellularorganism

Features
Gene ID: ENSMUSG00000044813
  
Biological name :Shb
  
Synonyms : Q6PD21 / SH2 domain-containing adapter protein B / Shb
  
Possible biological names infered from orthology : AL138752.2 / Q15464 / SH2 domain containing adaptor protein B
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: B1
Gene start: 45423278
Gene end: 45532470
  
Corresponding Affymetrix probe sets: 10512714 (MoGene1.0st)   1434153_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000060433
Ensembl peptide - ENSMUSP00000123176
Ensembl peptide - ENSMUSP00000115331
NCBI entrez gene - 230126     See in Manteia.
MGI - MGI:98294
RefSeq - NM_001033306
RefSeq Peptide - NP_001028478
swissprot - A2AKW4
swissprot - A2AKW1
swissprot - Q6PD21
Ensembl - ENSMUSG00000044813
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000026811Gallus gallus
 AL138752.2ENSG00000255872Homo sapiens
 SHBENSG00000107338Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Shd / O88834 / SH2 domain-containing adapter protein D / Q96IW2* / Src homology 2 domain containing transforming protein D*ENSMUSG0000003915432
Shf / Q8CG80 / SH2 domain-containing adapter protein F / Q7M4L6* / Src homology 2 domain containing F*ENSMUSG0000003325629
She / Q8BSD5 / SH2 domain-containing adapter protein E / Q5VZ18* / Src homology 2 domain containing E*ENSMUSG0000004628028


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR035040  SH2 domain-containing adapter protein B
 IPR035045  SHB, SH2 domain
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
anatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell deathcell communicationcellular response to stimuluscellular developmental processcell activationleukocyte proliferationimmune responseimmune effector processcell adhesioncell cyclestem cell proliferationmulticellular organism reproductiondevelopmental maturationanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell deathcell communicationcellular response to stimuluscellular developmental processcell activationleukocyte proliferationimmune responseimmune effector processcell adhesioncell cyclestem cell proliferationmulticellular organism reproductiondevelopmental maturationanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell deathcell communicationcellular response to stimuluscellular developmental processcell activationleukocyte proliferationimmune responseimmune effector processcell adhesioncell cyclestem cell proliferationmulticellular organism reproductiondevelopmental maturationanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell deathcell communicationcellular response to stimuluscellular developmental processcell activationleukocyte proliferationimmune responseimmune effector processcell adhesioncell cyclestem cell proliferationmulticellular organism reproductiondevelopmental maturationanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell deathcell communicationcellular response to stimuluscellular developmental processcell activationleukocyte proliferationimmune responseimmune effector processcell adhesioncell cyclestem cell proliferationmulticellular organism reproductiondevelopmental maturationanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell deathcell communicationcellular response to stimuluscellular developmental processcell activationleukocyte proliferationimmune responseimmune effector processcell adhesioncell cyclestem cell proliferationmulticellular organism reproductiondevelopmental maturationanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell deathcell communicationcellular response to stimuluscellular developmental processcell activationleukocyte proliferationimmune responseimmune effector processcell adhesioncell cyclestem cell proliferationmulticellular organism reproductiondevelopmental maturationanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell deathcell communicationcellular response to stimuluscellular developmental processcell activationleukocyte proliferationimmune responseimmune effector processcell adhesioncell cyclestem cell proliferationmulticellular organism reproductiondevelopmental maturationanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell deathcell communicationcellular response to stimuluscellular developmental processcell activationleukocyte proliferationimmune responseimmune effector processcell adhesioncell cyclestem cell proliferationmulticellular organism reproductiondevelopmental maturationanatomical structure developmentnitrogen compound metabolic processcellular metabolic processprimary metabolic processregulation of molecular functionorganic substance metabolic processcell deathcell communicationcellular response to stimuluscellular developmental processcell activationleukocyte proliferationimmune responseimmune effector processcell adhesioncell cyclestem cell proliferationmulticellular organism reproductiondevelopmental maturationanatomianatomical structure developmentnitrogenitrogen compound metabolic processcellulacellular metabolic processprimaryprimary metabolic processregulatregulation of molecular functionorganicorganic substance metabolic processcell decell deathcell cocell communicationcellulacellular response to stimuluscellulacellular developmental processcell accell activationleukocyleukocyte proliferationimmune immune responseimmune immune effector processcell adcell adhesioncell cycell cyclestem cestem cell proliferationmulticemulticellular organism reproductiondevelopdevelopmental maturation
protein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingmolecular adaptor activityprotein bindingprotein bindingmolecular adaptor activitymolecular adaptor activity
cellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellorganellemembrane-enclosed lumenmembraneprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembraneprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0006469 negative regulation of protein kinase activity IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0042100 B cell proliferation IDA
 biological_processGO:0045624 positive regulation of T-helper cell differentiation IMP
 biological_processGO:0045931 positive regulation of mitotic cell cycle IMP
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0050852 T cell receptor signaling pathway IMP
 biological_processGO:0071425 hematopoietic stem cell proliferation IMP
 biological_processGO:1900194 negative regulation of oocyte maturation IMP
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule ISO
 molecular_functionGO:0001784 phosphotyrosine residue binding ISO
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0005515 protein binding IDA


Pathways (from Reactome)
Pathway description
EPHB-mediated forward signaling
VEGFA-VEGFR2 Pathway


Phenotype (from MGI, Zfin or HPO)
nervous system phenotypeembryogenesis phenotypecardiovascular system phenotypereproductive system phenotypelimbs/digits/tail phenotypemortality/agingnervous system phenotypeembryogenesis phenotypecardiovascular system phenotypereproductive system phenotypelimbs/digits/tail phenotypemortality/agingnervous system phenotypeembryogenesis phenotypecardiovascular system phenotypereproductive system phenotypelimbs/digits/tail phenotypemortality/agingnervous system phenotypeembryogenesis phenotypecardiovascular system phenotypereproductive system phenotypelimbs/digits/tail phenotypemortality/agingnervous system phenotypeembryogenesis phenotypecardiovascular system phenotypereproductive system phenotypelimbs/digits/tail phenotypemortality/agingnervous system phenotypeembryogenesis phenotypecardiovascular system phenotypereproductive system phenotypelimbs/digits/tail phenotypemortality/agingnervous system phenotypeembryogenesis phenotypecardiovascular system phenotypereproductive system phenotypelimbs/digits/tail phenotypemortality/agingnervous system phenotypeembryogenesis phenotypecardiovascular system phenotypereproductive system phenotypelimbs/digits/tail phenotypemortality/agingnervous system phenotypeembryogenesis phenotypecardiovascular system phenotypereproductive system phenotypelimbs/digits/tail phenotypemortality/agingnervous system phenotypeembryogenesis phenotypecardiovascular system phenotypereproductive system phenotypelimbs/digits/tail phenotypemortality/agingnervous system phenotypnervous system phenotypeembryogenesis phenotypeembryogenesis phenotypecardiovascular system pcardiovascular system phenotypereproductive system phereproductive system phenotypelimbs/digits/tail phenolimbs/digits/tail phenotypemortality/agingmortality/aging
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

Allelic Composition: Shbtm1.1Miwe/Shb+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Shbtm1.1Miwe/Shb+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0006281 abnormal tail development "anomaly in the formation of the tail" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Shbtm1.1Miwe/Shb+
Genetic Background: involves: 129X1/SvJ * C57BL/6 * FVB/N

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007815 Rhoa / Q9QUI0 / ras homolog family member A / P61586*  / reaction
 ENSMUSG00000020580 Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*  / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / reaction
 ENSMUSG00000021270 P07901 / Hsp90aa1 / Heat shock protein HSP 90-alpha / P07900* / heat shock protein 90 alpha family class A member 1*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction / complex
 ENSMUSG00000059456 Ptk2b / Q9QVP9 / PTK2 protein tyrosine kinase 2 beta / Q14289* / protein tyrosine kinase 2 beta*  / reaction
 ENSMUSG00000027087 Itgav / P43406 / Integrin alpha-V Integrin alpha-V heavy chain Integrin alpha-V light chain / P06756* / integrin subunit alpha V*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000024290 Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*  / reaction
 ENSMUSG00000041112 Elmo1 / Q8BPU7 / Engulfment and cell motility protein 1 / Q92556* / engulfment and cell motility 1*  / complex / reaction
 ENSMUSG00000029528 Pxn / Q8VI36 / Paxillin / P49023*  / complex / reaction
 ENSMUSG00000017670 Elmo2 / Q8BHL5 / Engulfment and cell motility protein 2 / Q96JJ3* / engulfment and cell motility 2*  / complex / reaction
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / complex






 

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