ENSMUSG00000017830


Mus musculus

Features
Gene ID: ENSMUSG00000017830
  
Biological name :Dhx58
  
Synonyms : Dhx58 / Probable ATP-dependent RNA helicase DHX58 / Q99J87
  
Possible biological names infered from orthology : DExH-box helicase 58 / Q96C10
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 100694884
Gene end: 100704271
  
Corresponding Affymetrix probe sets: 10391207 (MoGene1.0st)   1420768_a_at (Mouse Genome 430 2.0 Array)   1420769_at (Mouse Genome 430 2.0 Array)   1451426_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000017974
NCBI entrez gene - 80861     See in Manteia.
MGI - MGI:1931560
RefSeq - NM_030150
RefSeq Peptide - NP_084426
swissprot - Q99J87
Ensembl - ENSMUSG00000017830
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx58ENSDARG00000089463Danio rerio
 DHX58ENSGALG00000023821Gallus gallus
 DHX58ENSG00000108771Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ifih1 / Q8R5F7 / Interferon-induced helicase C domain-containing protein 1 / Q9BYX4* / interferon induced with helicase C domain 1*ENSMUSG0000002689642
Ddx58 / Q6Q899 / Probable ATP-dependent RNA helicase DDX58 / O95786* / DExD/H-box helicase 58*ENSMUSG0000004029632
Dicer1 / dicer 1, ribonuclease III / Q9UPY3*ENSMUSG0000004141522
Fancm / Q8BGE5 / Fanconi anemia group M protein homolog / Q8IYD8* / Fanconi anemia complementation group M*ENSMUSG0000005588419


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR006935  Helicase/UvrB, N-terminal
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR021673  RIG-I-like receptor, C-terminal regulatory domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0032480 negative regulation of type I interferon production IEA
 biological_processGO:0032481 positive regulation of type I interferon production IMP
 biological_processGO:0039534 negative regulation of MDA-5 signaling pathway IEA
 biological_processGO:0039536 negative regulation of RIG-I signaling pathway IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045088 regulation of innate immune response IEA
 biological_processGO:0045824 negative regulation of innate immune response IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:1900245 positive regulation of MDA-5 signaling pathway IMP
 biological_processGO:1900246 positive regulation of RIG-I signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001144 fused vaginal opening "condition in which the external vaginal opening is closed by the adherence of the epithelium of the vagina" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhx58tm1Aki/Dhx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Dhx58tm1Aki/Dhx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dhx58tm1Itl/Dhx58tm1Itl
Genetic Background: C57BL/6-Dhx58tm1Itl

 MP:0004906 enlarged uterus 
Show

Allelic Composition: Dhx58tm1Aki/Dhx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhx58tm1Itl/Dhx58tm1Itl
Genetic Background: C57BL/6-Dhx58tm1Itl

 MP:0008555 abnormal interferon secretion "anomaly in the production or release of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Dhx58tm1Itl/Dhx58tm1Itl
Genetic Background: C57BL/6-Dhx58tm1Itl

 MP:0008562 increased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008564 increased interferon-beta secretion "increase in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Dhx58tm1Aki/Dhx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dhx58tm1Itl/Dhx58tm1Itl
Genetic Background: C57BL/6-Dhx58tm1Itl

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Dhx58tm1Itl/Dhx58tm1Itl
Genetic Background: C57BL/6-Dhx58tm1Itl

 MP:0008576 decreased circulating interferon-beta level "reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Dhx58tm1Aki/Dhx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008617 increased circulating interleukin-12 level "increase in the amount in the blood of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Dhx58tm1Aki/Dhx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Il6sttm1Wme/Il6sttm1Wme,Tg(Alb1-cre)7Gsc/?
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhx58tm1Aki/Dhx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dhx58tm2.1Aki/Dhx58tm2.1Aki
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Dhx58tm1Itl/Dhx58tm1Itl
Genetic Background: C57BL/6-Dhx58tm1Itl

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Dhx58tm1Aki/Dhx58tm1Aki
Genetic Background: involves: 129/Sv * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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