ENSMUSG00000018774


Mus musculus

Features
Gene ID: ENSMUSG00000018774
  
Biological name :Cd68
  
Synonyms : Cd68 / Macrosialin / P31996
  
Possible biological names infered from orthology : CD68 molecule / P34810
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69664213
Gene end: 69666153
  
Corresponding Affymetrix probe sets: 10387536 (MoGene1.0st)   1449164_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104294
Ensembl peptide - ENSMUSP00000018918
NCBI entrez gene - 12514     See in Manteia.
MGI - MGI:88342
RefSeq - NM_001291058
RefSeq Peptide - NP_001277987
swissprot - A0A0R4J1C8
swissprot - P31996
Ensembl - ENSMUSG00000018774
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:ch211-212k18.7ENSDARG00000055504Danio rerio
 CD68ENSG00000129226Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lamp1 / P11438 / Lysosome-associated membrane glycoprotein 1 / P11279* / lysosomal associated membrane protein 1*ENSMUSG0000003144725
Lamp2 / P17047 / Lysosome-associated membrane glycoprotein 2 / P13473* / lysosomal associated membrane protein 2*ENSMUSG0000001653424
Lamp3 / Q7TST5 / Lysosome-associated membrane glycoprotein 3 / Q9UQV4* / lysosomal associated membrane protein 3*ENSMUSG0000004124719


Protein motifs (from Interpro)
Interpro ID Name
 IPR002000  Lysosome-associated membrane glycoprotein
 IPR018134  Lysosome-associated membrane glycoprotein, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0071310 cellular response to organic substance IDA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0010008 endosome membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0002455 abnormal dendritic cell antigen presentation "impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Wnt7atm1.1Tesp/Wnt7atm1.1Tesp,Pgrtm2(cre)Lyd/Pgr+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6 * SJL

 MP:0004982 abnormal osteoclast morphology "any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0004993 decreased bone resorption "reduced amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0010868 increased bone trabecula number "increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0010875 increased bone volume "increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

 MP:0020080 increased bone mineralization "increase in the rate at which minerals are deposited into bone" [ORCID: orcid.org/0000-0003-4606-0597]
Show

Allelic Composition: Aqp4tm1.1Geno/Aqp4tm1.1Geno,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: C57BL/6J * FVB/N

Allelic Composition: Cd68tm1Xfen/Cd68+
Genetic Background: C57BL/6J-Cd68tm1Xfen

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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