ENSMUSG00000019487


Mus musculus

Features
Gene ID: ENSMUSG00000019487
  
Biological name :Trip10
  
Synonyms : Q8CJ53 / thyroid hormone receptor interactor 10 / Trip10
  
Possible biological names infered from orthology : Q15642
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: D
Gene start: 57249455
Gene end: 57263665
  
Corresponding Affymetrix probe sets: 10446235 (MoGene1.0st)   1418092_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000153081
Ensembl peptide - ENSMUSP00000153576
Ensembl peptide - ENSMUSP00000153606
Ensembl peptide - ENSMUSP00000019631
Ensembl peptide - ENSMUSP00000153467
NCBI entrez gene - 106628     See in Manteia.
MGI - MGI:2146901
RefSeq - XM_006523401
RefSeq - NM_001242389
RefSeq - NM_001242390
RefSeq - NM_001242391
RefSeq - NM_134125
RefSeq - XM_006523400
RefSeq Peptide - NP_001229319
RefSeq Peptide - NP_001229320
RefSeq Peptide - NP_598886
RefSeq Peptide - NP_001229318
swissprot - Q8CJ53
swissprot - A0A286YEA1
Ensembl - ENSMUSG00000019487
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trip10aENSDARG00000005679Danio rerio
 trip10bENSDARG00000100788Danio rerio
 Q15642ENSG00000125733Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fnbp1l / formin binding protein 1 like / Q5T0N5*ENSMUSG0000003973554
Fnbp1 / Q80TY0 / Mus musculus formin binding protein 1 (Fnbp1), transcript variant 6, mRNA. / Q96RU3* / formin binding protein 1*ENSMUSG0000007541552


Protein motifs (from Interpro)
Interpro ID Name
 IPR001060  FCH domain
 IPR001452  SH3 domain
 IPR027267  AH/BAR domain superfamily
 IPR028498  Cdc42-interacting protein 4
 IPR031160  F-BAR domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006897 endocytosis IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 cellular_componentGO:0001891 phagocytic cup IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0042802 identical protein binding ISO


Pathways (from Reactome)
Pathway description
Rho GTPase cycle
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002359 abnormal spleen germinal center morphology "anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Btkxid/Y,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129S4/SvJae * CBA/CaHN

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+,Psen1tm1Mpm/Psen1tm1Mpm,Tg(APPSwe,tauP301L)1Lfa/0,Tg(Thy1-YFP)HJrs/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
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Allelic Composition: Btkxid/Y,Ikzf3tm1Kge/Ikzf3tm1Kge
Genetic Background: involves: 129S4/SvJae * CBA/CaHN

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019487 Q8CJ53 / Trip10 / thyroid hormone receptor interactor 10 / Q15642*  / complex






 

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