ENSMUSG00000020399


Mus musculus

Features
Gene ID: ENSMUSG00000020399
  
Biological name :Havcr2
  
Synonyms : Havcr2 / Hepatitis A virus cellular receptor 2 homolog / Q8VIM0
  
Possible biological names infered from orthology : hepatitis A virus cellular receptor 2 / Q8TDQ0
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.1
Gene start: 46454935
Gene end: 46481255
  
Corresponding Affymetrix probe sets: 10375443 (MoGene1.0st)   1451584_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104852
Ensembl peptide - ENSMUSP00000020668
NCBI entrez gene - 171285     See in Manteia.
MGI - MGI:2159682
RefSeq - NM_134250
RefSeq Peptide - NP_599011
swissprot - D3Z3I4
swissprot - Q8VIM0
Ensembl - ENSMUSG00000020399
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 timd4ENSDARG00000077257Danio rerio
 HAVCR1ENSGALG00000017362Gallus gallus
 HAVCR2ENSG00000135077Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Havcr1 / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000004040526
Timd2 / T cell immunoglobulin and mucin domain containing 2 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000004041325
Timd4 / Q6U7R4 / T-cell immunoglobulin and mucin domain-containing protein 4 / Q96H15* / T cell immunoglobulin and mucin domain containing 4*ENSMUSG0000005554625
Gm12169 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000007892423
BC053393 / cDNA sequence BC053393 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000004697420


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001819 positive regulation of cytokine production IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002281 macrophage activation involved in immune response IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002519 natural killer cell tolerance induction IEA
 biological_processGO:0002652 regulation of tolerance induction dependent upon immune response IMP
 biological_processGO:0002826 negative regulation of T-helper 1 type immune response IMP
 biological_processGO:0002838 negative regulation of immune response to tumor cell IMP
 biological_processGO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0010629 negative regulation of gene expression IEA
 biological_processGO:0030886 negative regulation of myeloid dendritic cell activation IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032480 negative regulation of type I interferon production IMP
 biological_processGO:0032687 negative regulation of interferon-alpha production IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032703 negative regulation of interleukin-2 production IEA
 biological_processGO:0032712 negative regulation of interleukin-3 production IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0032722 positive regulation of chemokine production IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032732 positive regulation of interleukin-1 production IMP
 biological_processGO:0032753 positive regulation of interleukin-4 production IEA
 biological_processGO:0032815 negative regulation of natural killer cell activation IMP
 biological_processGO:0034138 toll-like receptor 3 signaling pathway IMP
 biological_processGO:0034154 toll-like receptor 7 signaling pathway IMP
 biological_processGO:0034162 toll-like receptor 9 signaling pathway IMP
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0043032 positive regulation of macrophage activation IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response IMP
 biological_processGO:0045824 negative regulation of innate immune response IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0060135 maternal process involved in female pregnancy IDA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0071222 cellular response to lipopolysaccharide IDA
 biological_processGO:0071656 negative regulation of granulocyte colony-stimulating factor production IEA
 biological_processGO:1900425 negative regulation of defense response to bacterium IMP
 biological_processGO:1900426 positive regulation of defense response to bacterium IMP
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IDA
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IEA
 biological_processGO:2000521 negative regulation of immunological synapse formation IMP
 biological_processGO:2001189 negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IEA
 cellular_componentGO:0001772 immunological synapse IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: AlbMhdabcl002/Alb+
Genetic Background: C3HeB/FeJ-AlbMhdabcl002

Allelic Composition: Havcr2tm1Vlcg/Havcr2tm1Vlcg,Tg(TcraTcrb)1100Mjb/?
Genetic Background: B6.Cg-Havcr2tm1Vlcg Tg(TcraTcrb)1100Mjb

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0005561 increased mean corpuscular hemoglobin "greater than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Grin2btm1e.1(KOMP)Wtsi/Grin2b+
Genetic Background: C57BL/6N-Grin2btm1e.1(KOMP)Wtsi/Tcp

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

Allelic Composition: Havcr2tm1Vlcg/Havcr2tm1Vlcg
Genetic Background: B6.129-Havcr2tm1Vlcg

Allelic Composition: Havcr2tm1Vlcg/Havcr2tm1Vlcg,Tg(TcraTcrb)1100Mjb/?
Genetic Background: B6.Cg-Havcr2tm1Vlcg Tg(TcraTcrb)1100Mjb

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0010181 decreased susceptibility to weight loss "smaller decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

 MP:0010677 decreased activation-induced cell death of T cells "decreased frequency of the type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors" [PMID:12752672]
Show

Allelic Composition: ApcMin/ApcMin
Genetic Background: involves: C57BL/6J * CAST/EiJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001123 Lgals9 / O08573 / Galectin-9 / Q6DKI2* / O00182* / Q3B8N2* / LGALS9B* / LGALS9C* / galectin 9B* / galectin 9C*  / complex / reaction






 

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