ENSMUSG00000055546


Mus musculus

Features
Gene ID: ENSMUSG00000055546
  
Biological name :Timd4
  
Synonyms : Q6U7R4 / T-cell immunoglobulin and mucin domain-containing protein 4 / Timd4
  
Possible biological names infered from orthology : Q96H15 / T cell immunoglobulin and mucin domain containing 4
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B1.1
Gene start: 46810800
Gene end: 46844332
  
Corresponding Affymetrix probe sets: 10375472 (MoGene1.0st)   1455318_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000069456
NCBI entrez gene - 276891     See in Manteia.
MGI - MGI:2445125
RefSeq - NM_178759
RefSeq - XM_006533479
RefSeq Peptide - NP_848874
swissprot - Q6U7R4
Ensembl - ENSMUSG00000055546
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 havcr1ENSDARG00000040178Danio rerio
 havcr2ENSDARG00000091692Danio rerio
 TIMD4ENSGALG00000003876Gallus gallus
 TIMD4ENSG00000145850Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Havcr1 / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000004040523
Havcr2 / Q8VIM0 / Hepatitis A virus cellular receptor 2 homolog / Q8TDQ0* / hepatitis A virus cellular receptor 2*ENSMUSG0000002039920
Timd2 / T cell immunoglobulin and mucin domain containing 2 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000004041320
Gm12169 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000007892415
BC053393 / cDNA sequence BC053393 / HAVCR1* / Q96D42* / hepatitis A virus cellular receptor 1*ENSMUSG0000004697414


Protein motifs (from Interpro)
Interpro ID Name
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013106  Immunoglobulin V-set domain
 IPR013783  Immunoglobulin-like fold
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001786 phosphatidylserine binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Slitrk5tm2Vlcg/Slitrk5+
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slitrk5tm2Vlcg/Slitrk5+
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: C57BL/6

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slitrk5tm2Vlcg/Slitrk5+
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Timd4tm1Kuch/Timd4tm1Kuch
Genetic Background: C57BL/6-Timd4tm1Kuch

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Fpr2tm1.2Jimw/Fpr2tm1.2Jimw
Genetic Background: B6.129X1-Fpr2tm1.2Jimw

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timd4tm1Kuch/Timd4tm1Kuch
Genetic Background: C57BL/6-Timd4tm1Kuch

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Timd4tm1Kuch/Timd4tm1Kuch
Genetic Background: C57BL/6-Timd4tm1Kuch

Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mfge8tm1Osa/Mfge8tm1Osa,Timd4tm1Osa/Timd4tm1Osa
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slitrk5tm2Vlcg/Slitrk5+
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slitrk5tm2Vlcg/Slitrk5+
Genetic Background: involves: 129S/Sv * C57BL/6

Allelic Composition: Timd4tm1Kuch/Timd4tm1Kuch
Genetic Background: C57BL/6-Timd4tm1Kuch

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Timd4tm1Kuch/Timd4tm1Kuch
Genetic Background: C57BL/6-Timd4tm1Kuch

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Slitrk5tm2Vlcg/Slitrk5+
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Slitrk5tm2Vlcg/Slitrk5+
Genetic Background: involves: 129S/Sv * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Timd4tm1Kuch/Timd4tm1Kuch
Genetic Background: C57BL/6-Timd4tm1Kuch

 MP:0008681 increased interleukin-17 secretion "increase in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Timd4tm1Kuch/Timd4tm1Kuch
Genetic Background: C57BL/6-Timd4tm1Kuch

 MP:0009336 increased splenocyte proliferation "increase in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Timd4tm1Kuch/Timd4tm1Kuch
Genetic Background: C57BL/6-Timd4tm1Kuch

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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