ENSMUSG00000020460


Mus musculus

Features
Gene ID: ENSMUSG00000020460
  
Biological name :Rps27a
  
Synonyms : P62983 / ribosomal protein S27A / Rps27a
  
Possible biological names infered from orthology : P62979
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A3.3
Gene start: 29545846
Gene end: 29548109
  
Corresponding Affymetrix probe sets: 10384829 (MoGene1.0st)   10541494 (MoGene1.0st)   10543052 (MoGene1.0st)   10553475 (MoGene1.0st)   10587501 (MoGene1.0st)   1449196_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099908
Ensembl peptide - ENSMUSP00000099909
NCBI entrez gene - 78294     See in Manteia.
MGI - MGI:1925544
RefSeq - NM_024277
RefSeq - NM_001033865
RefSeq Peptide - NP_001029037
RefSeq Peptide - NP_077239
swissprot - P62983
swissprot - Q642L7
Ensembl - ENSMUSG00000020460
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rps27aENSDARG00000032725Danio rerio
 P79781ENSGALG00000036790Gallus gallus
 P62979ENSG00000143947Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR002906  Ribosomal protein S27a
 IPR011332  Zinc-binding ribosomal protein
 IPR019954  Ubiquitin conserved site
 IPR019956  Ubiquitin
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0007623 circadian rhythm TAS
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0022627 cytosolic small ribosomal subunit ISO
 cellular_componentGO:0043209 myelin sheath IDA
 molecular_functionGO:0003735 structural constituent of ribosome IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
AUF1 (hnRNP D0) binds and destabilizes mRNA
APC-Cdc20 mediated degradation of Nek2A
ABC-family proteins mediated transport
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
Asymmetric localization of PCP proteins
CDK-mediated phosphorylation and removal of Cdc6
CLEC7A (Dectin-1) signaling
Degradation of DVL
Cyclin D associated events in G1
DNA Damage Recognition in GG-NER
Degradation of GLI1 by the proteasome
Degradation of beta-catenin by the destruction complex
Downregulation of ERBB2:ERBB3 signaling
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Downregulation of TGF-beta receptor signaling
Endosomal Sorting Complex Required For Transport (ESCRT)
Downregulation of ERBB2 signaling
EGFR downregulation
Dual incision in TC-NER
Downstream TCR signaling
Formation of TC-NER Pre-Incision Complex
Fanconi Anemia Pathway
GLI3 is processed to GLI3R by the proteasome
HDR through Homologous Recombination (HRR)
Hedgehog on state
Gap-filling DNA repair synthesis and ligation in TC-NER
Interleukin-1 signaling
Iron uptake and transport
MAPK6/MAPK4 signaling
NF-kB is activated and signals survival
NOD1/2 Signaling Pathway
Negative regulation of MAPK pathway
Negative regulation of FGFR1 signaling
Neddylation
Orc1 removal from chromatin
Negative regulation of MET activity
Negative regulation of FGFR3 signaling
Oncogene Induced Senescence
NRIF signals cell death from the nucleus
Peroxisomal protein import
Ovarian tumor domain proteases
Regulation of PTEN stability and activity
Regulation of FZD by ubiquitination
Regulation of PLK1 Activity at G2/M Transition
Regulation of necroptotic cell death
Regulation of RUNX2 expression and activity
Regulation of RAS by GAPs
SCF(Skp2)-mediated degradation of p27/p21
Regulation of signaling by CBL
Regulation of expression of SLITs and ROBOs
Regulation of RUNX3 expression and activity
Regulation of TP53 Activity through Methylation
Regulation of TP53 Degradation
Regulation of TNFR1 signaling
Regulation of innate immune responses to cytosolic DNA
Senescence-Associated Secretory Phenotype (SASP)
Stabilization of p53
Stimuli-sensing channels
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Termination of translesion DNA synthesis
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
TNFR2 non-canonical NF-kB pathway
Translesion synthesis by POLI
Ub-specific processing proteases
Translesion synthesis by POLK
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
UCH proteinases
Ubiquitin-dependent degradation of Cyclin D1
p75NTR recruits signalling complexes
Separation of Sister Chromatids
Downregulation of ERBB4 signaling
NIK-->noncanonical NF-kB signaling
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Regulation of PTEN localization
TNFR1-induced NFkappaB signaling pathway
Formation of the ternary complex, and subsequently, the 43S complex
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Cargo recognition for clathrin-mediated endocytosis
APC/C:Cdc20 mediated degradation of Securin
IKK complex recruitment mediated by RIP1
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Negative regulation of FGFR4 signaling
Autodegradation of the E3 ubiquitin ligase COP1
SCF-beta-TrCP mediated degradation of Emi1
Autodegradation of Cdh1 by Cdh1:APC/C
Negative regulators of DDX58/IFIH1 signaling
Formation of Incision Complex in GG-NER
TCF dependent signaling in response to WNT
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
CDT1 association with the CDC6:ORC:origin complex
Ribosomal scanning and start codon recognition
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Metalloprotease DUBs
FCERI mediated NF-kB activation
Hedgehog ligand biogenesis
Regulation of TP53 Activity through Phosphorylation
Translesion Synthesis by POLH
APC/C:Cdc20 mediated degradation of Cyclin B
Translesion synthesis by REV1
The role of GTSE1 in G2/M progression after G2 checkpoint
Oxidative Stress Induced Senescence
G2/M Checkpoints
NOTCH3 Activation and Transmission of Signal to the Nucleus
Spry regulation of FGF signaling
Clathrin-mediated endocytosis
Glycogen synthesis
Deactivation of the beta-catenin transactivating complex
Josephin domain DUBs
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
ER Quality Control Compartment (ERQC)
E3 ubiquitin ligases ubiquitinate target proteins
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Dual Incision in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Negative regulation of FGFR2 signaling
Dectin-1 mediated noncanonical NF-kB signaling
Degradation of AXIN
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
activated TAK1 mediates p38 MAPK activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Activated NOTCH1 Transmits Signal to the Nucleus
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Recognition of DNA damage by PCNA-containing replication complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022111 Uchl3 / Q9JKB1 / ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) / P15374* / ubiquitin C-terminal hydrolase L3*  / reaction
 ENSMUSG00000035337 Uchl4 / P58321 / ubiquitin carboxyl-terminal esterase L4 / UCHL3* / P15374* / ubiquitin C-terminal hydrolase L3*  / reaction
 ENSMUSG00000031010 Usp9x / ubiquitin specific peptidase 9, X chromosome / Q93008* / ubiquitin specific peptidase 9, X-linked*  / reaction
 ENSMUSG00000022710 Usp7 / ubiquitin specific peptidase 7 / Q93009*  / reaction






 

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