ENSMUSG00000020847


Mus musculus

Features
Gene ID: ENSMUSG00000020847
  
Biological name :Rph3al
  
Synonyms : Q768S4 / Rab effector Noc2 / Rph3al
  
Possible biological names infered from orthology : Q9UNE2 / rabphilin 3A like (without C2 domains)
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B5
Gene start: 75830999
Gene end: 75938429
  
Corresponding Affymetrix probe sets: 10388476 (MoGene1.0st)   1431695_at (Mouse Genome 430 2.0 Array)   1444409_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000064202
Ensembl peptide - ENSMUSP00000113869
Ensembl peptide - ENSMUSP00000121304
Ensembl peptide - ENSMUSP00000021208
Ensembl peptide - ENSMUSP00000104058
NCBI entrez gene - 380714     See in Manteia.
MGI - MGI:1923492
RefSeq - XM_011249102
RefSeq - NM_001291159
RefSeq - NM_029548
RefSeq - XM_006533641
RefSeq - XM_006533642
RefSeq - XM_006533643
RefSeq - XM_011249101
RefSeq - XM_006533637
RefSeq - XM_006533638
RefSeq - XM_006533639
RefSeq - XM_006533640
RefSeq Peptide - NP_001278088
RefSeq Peptide - NP_083824
swissprot - Q768S4
swissprot - B7FAU1
Ensembl - ENSMUSG00000020847
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rph3alENSDARG00000044290Danio rerio
 RPH3ALENSGALG00000037314Gallus gallus
 Q9UNE2ENSG00000181031Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR010911  Rab-binding domain
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR017455  Zinc finger, FYVE-related
 IPR030538  Rab effector Noc2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0017157 regulation of exocytosis IEA
 biological_processGO:0017158 regulation of calcium ion-dependent exocytosis IMP
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IMP
 biological_processGO:0050714 positive regulation of protein secretion IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030141 secretory granule IEA
 cellular_componentGO:0030658 transport vesicle membrane IEA
 cellular_componentGO:0030667 secretory granule membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 molecular_functionGO:0005509 calcium ion binding IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005544 calcium-dependent phospholipid binding IBA
 molecular_functionGO:0017137 Rab GTPase binding IEA
 molecular_functionGO:0030274 LIM domain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003059 decreased insulin secretion "less than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

 MP:0009161 pancreatic acinar cell zymogen granule accumulation "a gradually increasing number of membrane-bounded, cytoplasmic secretory granules found in pancreatic acinar cells that contain inactive digestive enzyme precursors" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Bdnftm3Jae/Bdnftm3Jae,Tg(Eno2tTA)5030Nes/0,Tg(tetO-cre)1Jaw/0
Genetic Background: involves: 129/Sv * C57BL/6 * ICR * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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