ENSMUSG00000021047


Mus musculus

Features
Gene ID: ENSMUSG00000021047
  
Biological name :Nova1
  
Synonyms : Nova1 / Q9JKN6 / RNA-binding protein Nova-1
  
Possible biological names infered from orthology : NOVA alternative splicing regulator 1 / P51513
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: B3
Gene start: 46694517
Gene end: 46818929
  
Corresponding Affymetrix probe sets: 10400155 (MoGene1.0st)   10400157 (MoGene1.0st)   1426938_at (Mouse Genome 430 2.0 Array)   1452245_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000151364
Ensembl peptide - ENSMUSP00000021438
Ensembl peptide - ENSMUSP00000151337
NCBI entrez gene - 664883     See in Manteia.
MGI - MGI:104297
RefSeq - XM_011244160
RefSeq - XM_006516151
RefSeq - XM_006516152
RefSeq - XM_006516153
RefSeq - XM_006516154
RefSeq - NM_021361
RefSeq - XM_006516150
RefSeq Peptide - NP_067336
swissprot - A0A1W2P6S8
swissprot - A0A1W2P6P4
swissprot - Q9JKN6
Ensembl - ENSMUSG00000021047
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOVA1ENSGALG00000009850Gallus gallus
 NOVA1ENSG00000139910Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nova2 / NOVA alternative splicing regulator 2 / Q9UNW9*ENSMUSG0000003041170
Pcbp3 / P57722 / Mus musculus poly(rC) binding protein 3 (Pcbp3), transcript variant 2, mRNA. / P57721* / poly(rC) binding protein 3*ENSMUSG0000000112021
Hnrnpk / P61979 / Heteroous nuclear ribonucleoprotein K / P61978* / heterogeneous nuclear ribonucleoprotein K*ENSMUSG0000002154621
Pcbp4 / poly(rC) binding protein 4 / P57723*ENSMUSG0000002349519
Pcbp1 / P60335 / Poly(rC)-binding protein 1 / Q15365*ENSMUSG0000005169519
Pcbp2 / Q61990 / Poly(rC)-binding protein 2 ENSMUSG0000005685119


Protein motifs (from Interpro)
Interpro ID Name
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR033086  RNA-binding protein Nova-1
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000398 mRNA splicing, via spliceosome IEA
 biological_processGO:0051252 regulation of RNA metabolic process IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Festm2Mcs/Fes+
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

 MP:0000746 weakness "state of being infirm or less strong than littermates" [J:45400]
Show

Allelic Composition: Festm2Mcs/Fes+
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Festm2Mcs/Fes+
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Festm2Mcs/Fes+
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Festm2Mcs/Fes+
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Festm2Mcs/Fes+
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Festm2Mcs/Fes+
Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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