ENSMUSG00000021123


Mus musculus

Features
Gene ID: ENSMUSG00000021123
  
Biological name :Rdh12
  
Synonyms : Q8BYK4 / Rdh12 / Retinol dehydrogenase 12
  
Possible biological names infered from orthology : Q96NR8 / retinol dehydrogenase 12 (all-trans/9-cis/11-cis)
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: C3
Gene start: 79208914
Gene end: 79222665
  
Corresponding Affymetrix probe sets: 10396840 (MoGene1.0st)   1424256_at (Mouse Genome 430 2.0 Array)   1431010_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112543
Ensembl peptide - ENSMUSP00000118851
Ensembl peptide - ENSMUSP00000021548
NCBI entrez gene - 77974     See in Manteia.
MGI - MGI:1925224
RefSeq - NM_030017
RefSeq - NM_001313971
RefSeq Peptide - NP_001300900
RefSeq Peptide - NP_084293
swissprot - Q8BYK4
swissprot - D3YY80
swissprot - A0A0R4J1M3
Ensembl - ENSMUSG00000021123
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rdh12ENSDARG00000018069Danio rerio
 ENSGALG00000009538Gallus gallus
 RDH12ENSG00000139988Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Rdh11 / Q9QYF1 / Retinol dehydrogenase 11 / Q8TC12* / retinol dehydrogenase 11 (all-trans/9-cis/11-cis)*ENSMUSG0000006644167
Rdh13 / Q8CEE7 / Retinol dehydrogenase 13 / Q8NBN7*ENSMUSG0000000843548
Rdh14 / Q9ERI6 / Retinol dehydrogenase 14 / Q9HBH5*ENSMUSG0000002062145
Dhrs13 / Q5SS80 / Dehydrogenase/reductase SDR family member 13 / Q6UX07* / dehydrogenase/reductase 13*ENSMUSG0000002083443
Wwox / Q91WL8 / WW domain-containing oxidoreductase / Q9NZC7*ENSMUSG0000000463740


Protein motifs (from Interpro)
Interpro ID Name
 IPR002347  Short-chain dehydrogenase/reductase SDR
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0042572 retinol metabolic process IEA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004745 retinol dehydrogenase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IBA


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003011 delayed dark adaptation "increase in time required for the eye to recover its sensitivity in the dark following exposure to bright lights" [J:68444, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Krt71Ca/Krt71+
Genetic Background: Not Specified

Allelic Composition: Rdh12tm1Kpal/Rdh12+
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Krt71Ca/Krt71+
Genetic Background: Not Specified

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Krt71Ca/Krt71+
Genetic Background: Not Specified

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Krt71Ca/Krt71+
Genetic Background: Not Specified

Allelic Composition: Rdh12tm1.1Cahb/Rdh12tm1.1Cahb
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006072 abnormal retinal apoptosis "increase or decrease in the number of cells in the retina undergoing programmed cell death" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
Show

Allelic Composition: Krt71Ca/Krt71+
Genetic Background: Not Specified

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krt71Ca/Krt71+
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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