ENSMUSG00000022052


Mus musculus

Features
Gene ID: ENSMUSG00000022052
  
Biological name :Ppp2r2a
  
Synonyms : Ppp2r2a / protein phosphatase 2, regulatory subunit B, alpha / Q6P1F6
  
Possible biological names infered from orthology : P63151 / protein phosphatase 2 regulatory subunit Balpha
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 67014056
Gene end: 67072444
  
Corresponding Affymetrix probe sets: 10421012 (MoGene1.0st)   1429715_at (Mouse Genome 430 2.0 Array)   1437730_at (Mouse Genome 430 2.0 Array)   1453260_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086640
Ensembl peptide - ENSMUSP00000153191
Ensembl peptide - ENSMUSP00000153452
NCBI entrez gene - 71978     See in Manteia.
MGI - MGI:1919228
RefSeq - XM_017316211
RefSeq - NM_001205188
RefSeq - NM_028032
RefSeq - XM_011245205
RefSeq Peptide - NP_082308
RefSeq Peptide - NP_001192117
swissprot - Q3TT94
swissprot - Q6P1F6
swissprot - Q9CWU3
swissprot - A0A286YDJ9
Ensembl - ENSMUSG00000022052
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r2aaENSDARG00000021996Danio rerio
 ppp2r2abENSDARG00000006624Danio rerio
 PPP2R2AENSGALG00000000235Gallus gallus
 P63151ENSG00000221914Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q925E7 / Ppp2r2d / protein phosphatase 2, regulatory subunit B, delta / Q66LE6* / protein phosphatase 2 regulatory subunit Bdelta*ENSMUSG0000004176988
Q6ZWR4 / Ppp2r2b / protein phosphatase 2, regulatory subunit B, beta / Q00005* / protein phosphatase 2 regulatory subunit Bbeta*ENSMUSG0000002450084
Q8BG02 / Ppp2r2c / protein phosphatase 2, regulatory subunit B, gamma / Q9Y2T4* / protein phosphatase 2 regulatory subunit Bgamma*ENSMUSG0000002912078


Protein motifs (from Interpro)
Interpro ID Name
 IPR000009  Protein phosphatase 2A regulatory subunit PR55
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR018067  Protein phosphatase 2A regulatory subunit PR55, conserved site
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IBA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0032502 developmental process IBA
 biological_processGO:0043278 response to morphine IMP
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0070262 peptidyl-serine dephosphorylation IBA
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 cellular_componentGO:0005829 cytosol IBA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA
 molecular_functionGO:0048156 tau protein binding IEA
 molecular_functionGO:0051721 protein phosphatase 2A binding IEA


Pathways (from Reactome)
Pathway description
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020349 P63330 / Ppp2ca / Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform / P67775* / protein phosphatase 2 catalytic subunit alpha*  / complex
 ENSMUSG00000007564 Q76MZ3 / Ppp2r1a / protein phosphatase 2, regulatory subunit A, alpha / P30153* / protein phosphatase 2 scaffold subunit Aalpha*  / complex
 ENSMUSG00000001517 Foxm1 / forkhead box M1 / Q08050*  / reaction






 

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