ENSMUSG00000022386


Mus musculus

Features
Gene ID: ENSMUSG00000022386
  
Biological name :Trmu
  
Synonyms : Q9DAT5 / Trmu / tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
  
Possible biological names infered from orthology : O75648
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: E2
Gene start: 85879312
Gene end: 85897394
  
Corresponding Affymetrix probe sets: 10426030 (MoGene1.0st)   1430828_at (Mouse Genome 430 2.0 Array)   1452786_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023019
Ensembl peptide - ENSMUSP00000125266
Ensembl peptide - ENSMUSP00000125704
NCBI entrez gene - 72026     See in Manteia.
MGI - MGI:1919276
RefSeq - XM_006521425
RefSeq - NM_028063
RefSeq - XM_006521422
RefSeq - XM_006521423
RefSeq - XM_006521424
RefSeq Peptide - NP_082339
swissprot - F7CNH0
swissprot - E0CZ49
swissprot - Q9DAT5
Ensembl - ENSMUSG00000022386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trmuENSDARG00000043734Danio rerio
 TRMUENSGALG00000031922Gallus gallus
 TRMUENSG00000100416Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004506  tRNA-specific 2-thiouridylase
 IPR014729  Rossmann-like alpha/beta/alpha sandwich fold
 IPR023382  Adenine nucleotide alpha hydrolase-like domains


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002143 tRNA wobble position uridine thiolation IBA
 biological_processGO:0008033 tRNA processing IEA
 biological_processGO:0070903 mitochondrial tRNA thio-modification IBA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 molecular_functionGO:0000049 tRNA binding IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016783 sulfurtransferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0000195 hypocalcemia "subnormal concentrations of calcium ions in the circulating blood " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Kpna7tm1.1Sgao/Kpna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kpna7tm1.1Sgao/Kpna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0003707 increased nucleus count "greater than one nuclei present per cell body when one is expected; often due to failed cytokinesis" [pg:Philip Groth submission]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0003806 abnormal nucleotide metabolism "impaired regulation of nucleotide levels in either production or breakdown of these structural components of nucleic acids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0006035 abnormal mitochondrial morphology "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0008805 decreased circulating amylase level "reduction in the concentration of a group of amylolytic enzymes that cleave starch, glycogen, and related alpha-1,4-glucans in the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:D08.811.277.450.066, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0010958 abnormal tricarboxylic acid cycle "any anomaly in the universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes; the acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle" [GO:0006099]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Kpna7tm1.1Sgao/Kpna7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0011635 abnormal mitochondrial crista morphology "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0011638 abnormal mitochondrial chromosome morphology "any structrual anomaly of the chromosome found in the mitochondrion of a eukaryotic cell" [GO:0000262]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0011971 increased circulating lactate dehydrogenase level "elevated blood level of the tetrameric enzyme that, along with the coenzyme NAD+, catalyzes the interconversion of lactate and pyruvate; measurements of circulating levels are used clinically as a diagnostic indicator of tissue breakdown, some forms of cancer or particular infection types" [MeSH:D08.811.682.047.551.400, MGI:csmith]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0013405 increased circulating lactate level "greater amount of lactate in the blood which is produced from pyruvate by lactate dehydrogenase" [MPD:Molly]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

 MP:0020427 increased hepatocyte karyomegaly "an increase in the number or proportion of liver cells with enlarged nuclei" [PMID:22733568, PMID:26980189, PMID:7731963, PMID:8701981, url:http://medical-dictionary.thefreedictionary.com/karyomegaly]
Show

Allelic Composition: Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Trmutm1Tomik/Trmutm1Tomik
Genetic Background: involves: C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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