ENSMUSG00000022617


Mus musculus
muscleChkbprocesskinasebiosyntheticactivitycholineethanolaminelipidbindingsynthesislevelskeletalfibershortradiusulnabowedproteinkinase-likedomainsuperfamilymetabolicphosphatidylethanolaminephosphatidylcholinecdp-cholinepathwayorgandevelopmentphospholipidphosphorylation

Features
Gene ID: ENSMUSG00000022617
  
Biological name :Chkb
  
Synonyms : Chkb / Choline/ethanolamine kinase / O55229
  
Possible biological names infered from orthology : CHKB-CPT1B / CHKB-CPT1B readthrough (NMD candidate) / choline kinase beta / Q9Y259
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E3
Gene start: 89426360
Gene end: 89429908
  
Corresponding Affymetrix probe sets: 10431585 (MoGene1.0st)   1448448_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023289
Ensembl peptide - ENSMUSP00000127191
Ensembl peptide - ENSMUSP00000128026
NCBI entrez gene - 12651     See in Manteia.
MGI - MGI:1328313
RefSeq - NM_007692
RefSeq Peptide - NP_031718
swissprot - Q54AG5
swissprot - F6RRT7
swissprot - F6SKI6
swissprot - O55229
Ensembl - ENSMUSG00000022617
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 chkbENSDARG00000063167Danio rerio
 CHKBENSG00000100288Homo sapiens
 CHKB-CPT1BENSG00000254413Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Chka / O54804 / Choline kinase alpha / P35790*ENSMUSG0000002484357
AC137513.1 / CHKB* / Q9Y259* / CHKB-CPT1B* / choline kinase beta* / CHKB-CPT1B readthrough (NMD candidate)*ENSMUSG0000011646141
Etnk2 / A7MCT6 / Ethanolamine kinase 2 / Q9NVF9*ENSMUSG0000007064428
Etnk1 / Q9D4V0 / Ethanolamine kinase 1 / Q9HBU6*ENSMUSG0000003027527


Protein motifs (from Interpro)
Interpro ID Name
 IPR011009  Protein kinase-like domain superfamily
 IPR026712  Choline/Ethanolamine kinase


Gene Ontology (GO)
primary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processnitrogen compound metabolic processanatomical structure developmentprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processnitrogen compound metabolic processanatomical structure developmentprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processnitrogen compound metabolic processanatomical structure developmentprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processnitrogen compound metabolic processanatomical structure developmentprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processnitrogen compound metabolic processanatomical structure developmentprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processnitrogen compound metabolic processanatomical structure developmentprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processnitrogen compound metabolic processanatomical structure developmentprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processnitrogen compound metabolic processanatomical structure developmentprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processnitrogen compound metabolic processanatomical structure developmentprimary metabolic processorganic substance metabolic processbiosynthetic processcellular metabolic processnitrogen compound metabolic processanatomical structure developmentprimary metabolic proceprimary metabolic processorganic substance metaborganic substance metabolic processbiosynthetic processbiosynthetic processcellular metabolic proccellular metabolic processnitrogen compound metabnitrogen compound metabolic processanatomical structure deanatomical structure development
organic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compound bindingheterocyclic compound bindingsmall molecule bindingtransferase activityion bindingcarbohydrate derivative bindingdrug bindingorganic cyclic compoorganic cyclic compound bindingheterocyclic compounheterocyclic compound bindingsmall molecule bindismall molecule bindingtransferase activitytransferase activityion bindingion bindingcarbohydrate derivatcarbohydrate derivative bindingdrug bindingdrug binding
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006646 phosphatidylethanolamine biosynthetic process ISO
 biological_processGO:0006656 phosphatidylcholine biosynthetic process IMP
 biological_processGO:0006657 CDP-choline pathway IEA
 biological_processGO:0007517 muscle organ development IMP
 biological_processGO:0008654 phospholipid biosynthetic process IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0046474 glycerophospholipid biosynthetic process IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004103 choline kinase activity ISO
 molecular_functionGO:0004305 ethanolamine kinase activity ISO
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of PC
Synthesis of PE


Phenotype (from MGI, Zfin or HPO)
limbs/digits/tail phenotypemuscle phenotypehomeostasis/metabolism phenotypeskeleton phenotypebehavior/neurological phenotypelimbs/digits/tail phenotypemuscle phenotypehomeostasis/metabolism phenotypeskeleton phenotypebehavior/neurological phenotypelimbs/digits/tail phenotypemuscle phenotypehomeostasis/metabolism phenotypeskeleton phenotypebehavior/neurological phenotypelimbs/digits/tail phenotypemuscle phenotypehomeostasis/metabolism phenotypeskeleton phenotypebehavior/neurological phenotypelimbs/digits/tail phenotypemuscle phenotypehomeostasis/metabolism phenotypeskeleton phenotypebehavior/neurological phenotypelimbs/digits/tail phenotypemuscle phenotypehomeostasis/metabolism phenotypeskeleton phenotypebehavior/neurological phenotypelimbs/digits/tail phenotypemuscle phenotypehomeostasis/metabolism phenotypeskeleton phenotypebehavior/neurological phenotypelimbs/digits/tail phenotypemuscle phenotypehomeostasis/metabolism phenotypeskeleton phenotypebehavior/neurological phenotypelimbs/digits/tail phenotypemuscle phenotypehomeostasis/metabolism phenotypeskeleton phenotypebehavior/neurological phenotypelimbs/digits/tail phenotypemuscle phenotypehomeostasis/metabolism phenotypeskeleton phenotypebehavior/neurological phenotypelimbs/digits/tail phenotypelimbs/digits/tail phenotypemuscle phenotypemuscle phenotypehomeostasis/metabolism phenohomeostasis/metabolism phenotypeskeleton phenotypeskeleton phenotypebehavior/neurological phenotbehavior/neurological phenotype
IDPhenotypeDefinition Genetic BG
 MP:0000550 abnormal forelimb morphology "malformation of the entire anterior extremities" [MGI:tc]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0000749 muscle degeneration "pathological deterioration of muscle tissue, often accompanied by loss of function" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0000752 dystrophic muscle "progressive weakness and wasting of muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67994]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0001547 abnormal lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0002106 abnormal muscle physiology "anomolous function of the muscle, not due to an anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0002932 abnormal joint "defect in the articulation point of two or more bones" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Agtpbp1babe/Agtpbp1babe
Genetic Background: C57BL/6JSfdAnu-Agtpbp1babe/Anu

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0004087 abnormal muscle fiber morphology "malformed or poorly developed muscle fibers, the cylindrical multinucleated muscle cells that contract when stimulated" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0004121 abnormal sarcolemma morphology "structural anomaly in the plasma membrane of a muscle fiber that is cabable of conducting electrical impuses" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0004355 short radius "reduced length of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Agtpbp1babe/Agtpbp1babe
Genetic Background: C57BL/6JSfdAnu-Agtpbp1babe/Anu

 MP:0004359 short ulna "reduced length of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Agtpbp1babe/Agtpbp1babe
Genetic Background: C57BL/6JSfdAnu-Agtpbp1babe/Anu

 MP:0004361 bowed ulna "increased curvature of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0005319 abnormal enzyme/ coenzyme level "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mdm2tm1Glo/Mdm2+,Mdm4Gt(VICTR20)7Lex/Mdm4+,Trp53tm1Wahl/Trp53tm1Wahl
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024843 Chka / O54804 / Choline kinase alpha / P35790*  / complex
 ENSMUSG00000022617 Chkb / O55229 / Choline/ethanolamine kinase / Q9Y259* / CHKB-CPT1B* / choline kinase beta* / CHKB-CPT1B readthrough (NMD candidate)*  / complex






 

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