ENSMUSG00000022935


Mus musculus

Features
Gene ID: ENSMUSG00000022935
  
Biological name :Grik1
  
Synonyms : Grik1 / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA.
  
Possible biological names infered from orthology : glutamate ionotropic receptor kainate type subunit 1 / P39086
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: C3.3
Gene start: 87895900
Gene end: 88290265
  
Corresponding Affymetrix probe sets: 10440621 (MoGene1.0st)   1427676_a_at (Mouse Genome 430 2.0 Array)   1439987_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154130
Ensembl peptide - ENSMUSP00000153786
Ensembl peptide - ENSMUSP00000154596
Ensembl peptide - ENSMUSP00000023652
Ensembl peptide - ENSMUSP00000072107
Ensembl peptide - ENSMUSP00000109773
Ensembl peptide - ENSMUSP00000147948
NCBI entrez gene - 14805     See in Manteia.
MGI - MGI:95814
RefSeq - XM_017316880
RefSeq - XM_006522915
RefSeq - XM_006522916
RefSeq - XM_006522917
RefSeq - XM_006522918
RefSeq - XM_006522919
RefSeq - XM_006522920
RefSeq - XM_006522921
RefSeq - NM_001346964
RefSeq - NM_010348
RefSeq - NM_146072
RefSeq - XM_006522914
RefSeq Peptide - NP_034478
RefSeq Peptide - NP_666184
RefSeq Peptide - NP_001333893
swissprot - F6QF13
swissprot - A0A1B0GSI4
swissprot - F6Z3M4
swissprot - E9Q2Y1
Ensembl - ENSMUSG00000022935
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grik1aENSDARG00000069139Danio rerio
 grik1bENSDARG00000040627Danio rerio
 GRIK1ENSGALG00000015835Gallus gallus
 GRIK1ENSG00000171189Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*ENSMUSG0000005607375
Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*ENSMUSG0000000198570
Grik5 / Q61626 / Glutamate receptor ionotropic, kainate 5 / Q16478* / glutamate ionotropic receptor kainate type subunit 5*ENSMUSG0000000337842
Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*ENSMUSG0000003201741
Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*ENSMUSG0000000198636
Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*ENSMUSG0000002052436
Gria2 / glutamate receptor 2 isoform 3 / P42262* / glutamate ionotropic receptor AMPA type subunit 2*ENSMUSG0000003398136
Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*ENSMUSG0000002589235
Grid1 / Q61627 / Glutamate receptor ionotropic, delta-1 / Q9ULK0* / glutamate ionotropic receptor delta type subunit 1*ENSMUSG0000004107828
Grid2 / Q61625 / Glutamate receptor ionotropic, delta-2 / O43424* / glutamate ionotropic receptor delta type subunit 2*ENSMUSG0000007142425
Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*ENSMUSG0000002695920
Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*ENSMUSG0000005900320
Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*ENSMUSG0000000277119
Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*ENSMUSG0000002073419
Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*ENSMUSG0000003020919
Grin3b / Q91ZU9 / Glutamate receptor ionotropic, NMDA 3B / O60391* / glutamate ionotropic receptor NMDA type subunit 3B*ENSMUSG0000003574519
Grin3a / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSMUSG0000003957919


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR001828  Receptor, ligand binding region
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
 IPR028082  Periplasmic binding protein-like I


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA


Pathways (from Reactome)
Pathway description
Activation of Na-permeable kainate receptors
Activation of Ca-permeable Kainate Receptor


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rag2tm2Fwa/Rag2tm2Fwa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0002886 abnormal glutamate receptor currents "change in the measured amplitude or duration of response to stimulation of glutmanergic receptors" [Principles of Neural Science, 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cacna1atg-rol/Cacna1atg-rol
Genetic Background: involves: C57BL/6 * SIII

 MP:0002945 abnormal inhibitory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an inhibitory impulse arrives at the synapse causing hyperpolarization" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

Allelic Composition: Grik1tm1Sfh/Grik1tm1Sfh,Grik2tm1Sfh/Grik2tm1Sfh
Genetic Background: involves: 129S/SvEv * 129S1/Sv * C57BL/6

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

 MP:0008531 increased chemical nociceptive threshold "a greater than average concentration at which chemically induced pain sensation is first detectable" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Snx1tm1Mag/Snx1+,Snx2tm1Mag/Snx2tm1Mag
Genetic Background: involves: 129/Sv * Black Swiss * Swiss Webster

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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