ENSMUSG00000035745


Mus musculus

Features
Gene ID: ENSMUSG00000035745
  
Biological name :Grin3b
  
Synonyms : Glutamate receptor ionotropic, NMDA 3B / Grin3b / Q91ZU9
  
Possible biological names infered from orthology : glutamate ionotropic receptor NMDA type subunit 3B / O60391
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 79970715
Gene end: 79977190
  
Corresponding Affymetrix probe sets: 10364583 (MoGene1.0st)   1449899_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048576
Ensembl peptide - ENSMUSP00000116887
Ensembl peptide - ENSMUSP00000122984
NCBI entrez gene - 170483     See in Manteia.
MGI - MGI:2150393
RefSeq - XM_006513287
RefSeq - XM_017313818
RefSeq - XM_017313819
RefSeq - NM_130455
RefSeq Peptide - NP_569722
swissprot - Q91ZU9
swissprot - F7ARC5
swissprot - F7BA29
Ensembl - ENSMUSG00000035745
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grin3baENSDARG00000005364Danio rerio
 grin3bbENSDARG00000098667Danio rerio
 GRIN3BENSGALG00000026241Gallus gallus
 GRIN3BENSG00000116032Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Grin3a / glutamate ionotropic receptor NMDA type subunit 3A / Q8TCU5*ENSMUSG0000003957952
Grin2d / Q03391 / Glutamate receptor ionotropic, NMDA 2D / O15399* / glutamate ionotropic receptor NMDA type subunit 2D*ENSMUSG0000000277125
Grin2c / Q01098 / Glutamate receptor ionotropic, NMDA 2C / Q14957* / glutamate ionotropic receptor NMDA type subunit 2C*ENSMUSG0000002073424
Grin2b / glutamate receptor, ionotropic, NMDA2B (epsilon 2) / Q13224* / glutamate ionotropic receptor NMDA type subunit 2B*ENSMUSG0000003020923
Grin2a / P35436 / Glutamate receptor ionotropic, NMDA 2A / Q12879* / glutamate ionotropic receptor NMDA type subunit 2A*ENSMUSG0000005900323
Grin1 / P35438 / Glutamate receptor ionotropic, NMDA 1 / Q05586* / glutamate ionotropic receptor NMDA type subunit 1*ENSMUSG0000002695920
Grik3 / B1AS29 / Glutamate receptor ionotropic, kainate 3 / Q13003* / glutamate ionotropic receptor kainate type subunit 3*ENSMUSG0000000198518
Grik5 / Q61626 / Glutamate receptor ionotropic, kainate 5 / Q16478* / glutamate ionotropic receptor kainate type subunit 5*ENSMUSG0000000337818
Grik1 / Mus musculus glutamate receptor, ionotropic, kainate 1 (Grik1), transcript variant 3, mRNA. / P39086* / glutamate ionotropic receptor kainate type subunit 1*ENSMUSG0000002293518
Gria3 / Q9Z2W9 / Mus musculus glutamate receptor, ionotropic, AMPA3 (alpha 3) (Gria3), transcript variant 5, mRNA. / P42263* / glutamate ionotropic receptor AMPA type subunit 3*ENSMUSG0000000198617
Gria1 / P23818 / Glutamate receptor 1 / P42261* / glutamate ionotropic receptor AMPA type subunit 1*ENSMUSG0000002052417
Gria4 / Q9Z2W8 / glutamate receptor, ionotropic, AMPA4 (alpha 4) / P48058* / glutamate ionotropic receptor AMPA type subunit 4*ENSMUSG0000002589217
Grik4 / Q8BMF5 / Glutamate receptor ionotropic, kainate 4 / Q16099* / glutamate ionotropic receptor kainate type subunit 4*ENSMUSG0000003201717
Grid1 / Q61627 / Glutamate receptor ionotropic, delta-1 / Q9ULK0* / glutamate ionotropic receptor delta type subunit 1*ENSMUSG0000004107817
Grik2 / P39087 / Glutamate receptor ionotropic, kainate 2 / Q13002* / glutamate ionotropic receptor kainate type subunit 2*ENSMUSG0000005607317
Gria2 / glutamate receptor 2 isoform 3 / P42262* / glutamate ionotropic receptor AMPA type subunit 2*ENSMUSG0000003398116
Grid2 / Q61625 / Glutamate receptor ionotropic, delta-2 / O43424* / glutamate ionotropic receptor delta type subunit 2*ENSMUSG0000007142416


Protein motifs (from Interpro)
Interpro ID Name
 IPR001320  Ionotropic glutamate receptor
 IPR001508  Ionotropic glutamate receptor, metazoa
 IPR019594  Ionotropic glutamate receptor, L-glutamate and glycine-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035235 ionotropic glutamate receptor signaling pathway IEA
 biological_processGO:0051205 protein insertion into membrane IMP
 biological_processGO:0051924 regulation of calcium ion transport IMP
 biological_processGO:0060079 excitatory postsynaptic potential IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex IMP
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0043025 neuronal cell body IMP
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0098794 postsynapse IEA
 molecular_functionGO:0004970 ionotropic glutamate receptor activity IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005234 extracellularly glutamate-gated ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001363 increased anxiety-related response "when compared to controls, subjects exhibit more responses thought to be indicative of anxiety in behavioral tests" [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:49752, J:53060]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002557 abnormal social/conspecific interaction "deviation of the normal behavior of mice towards each other" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nr3c1tm1Gsc/Nr3c1tm1Gsc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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