ENSMUSG00000022994


Mus musculus

Features
Gene ID: ENSMUSG00000022994
  
Biological name :Adcy6
  
Synonyms : Adcy6 / adenylate cyclase 6
  
Possible biological names infered from orthology : O43306
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: F1
Gene start: 98589973
Gene end: 98610076
  
Corresponding Affymetrix probe sets: 10432190 (MoGene1.0st)   1418128_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154421
Ensembl peptide - ENSMUSP00000093939
Ensembl peptide - ENSMUSP00000154012
Ensembl peptide - ENSMUSP00000154693
Ensembl peptide - ENSMUSP00000154696
NCBI entrez gene - 11512     See in Manteia.
MGI - MGI:87917
RefSeq - XM_017316367
RefSeq - NM_007405
RefSeq - XM_006520314
RefSeq - XM_006520315
RefSeq - XM_006520303
RefSeq - XM_006520306
RefSeq - XM_006520307
RefSeq Peptide - NP_031431
swissprot - F8VQ52
Ensembl - ENSMUSG00000022994
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adcy6aENSDARG00000061445Danio rerio
 adcy6bENSDARG00000027797Danio rerio
 ADCY6ENSG00000174233Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adcy5 / P84309 / Adenylate cyclase type 5 / O95622* / adenylate cyclase 5*ENSMUSG0000002284067
Adcy8 / P97490 / Adenylate cyclase type 8 / P40145* / adenylate cyclase 8*ENSMUSG0000002237639
Adcy1 / O88444 / Adenylate cyclase type 1 / Q08828* / adenylate cyclase 1*ENSMUSG0000002043138
Adcy2 / adenylate cyclase 2 / Q08462*ENSMUSG0000002153635
Adcy4 / Q91WF3 / Adenylate cyclase type 4 / Q8NFM4* / adenylate cyclase 4*ENSMUSG0000002222034
Adcy3 / Q8VHH7 / Adenylate cyclase type 3 / O60266* / adenylate cyclase 3*ENSMUSG0000002065433
Adcy7 / P51829 / Adenylate cyclase type 7 / P51828* / adenylate cyclase 7*ENSMUSG0000003165933
Adcy9 / P51830 / Adenylate cyclase type 9 / O60503* / adenylate cyclase 9*ENSMUSG0000000558026


Protein motifs (from Interpro)
Interpro ID Name
 IPR001054  Adenylyl cyclase class-3/4/guanylyl cyclase
 IPR009398  Adenylate cyclase, conserved domain
 IPR018297  Adenylyl cyclase class-4/guanylyl cyclase, conserved site
 IPR029787  Nucleotide cyclase
 IPR030672  Adenylate cyclase
 IPR032628  Adenylate cyclase, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006171 cAMP biosynthetic process IEA
 biological_processGO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007212 dopamine receptor signaling pathway IEA
 biological_processGO:0009190 cyclic nucleotide biosynthetic process IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0071380 cellular response to prostaglandin E stimulus IEA
 biological_processGO:0071870 cellular response to catecholamine stimulus IEA
 biological_processGO:0097746 regulation of blood vessel diameter IEA
 biological_processGO:1904322 cellular response to forskolin IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004016 adenylate cyclase activity IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0016849 phosphorus-oxygen lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Glucagon signaling in metabolic regulation
PKA activation
PKA activation in glucagon signalling
Adenylate cyclase activating pathway
Adenylate cyclase inhibitory pathway
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Adrenaline,noradrenaline inhibits insulin secretion
G alpha (s) signalling events
G alpha (z) signalling events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo,Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adcy6tm2Yich/Adcy6tm2Yich
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Adcy3tm1.1Dek/Adcy3tm1.1Dek,Adcy6tm1.1Dek/Adcy6tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Diaph1tm1.1Sna/Diaph1tm1.1Sna,Diaph2tm1.2Sna/Y
Genetic Background: B6N.Cg-Diaph1tm1.1Sna Diahp2tm1.2Sna

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: A830005F24Riktm1.1(KOMP)Mbp/A830005F24Rik+
Genetic Background: C57BL/6N-A830005F24Riktm1.1(KOMP)Mbp/Ucd

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo,Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adcy6tm2Yich/Adcy6tm2Yich
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Adcy6tm1.1Dek/Adcy6tm1.1Dek,Tg(Aqp2-cre)1Dek/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

Allelic Composition: Adcy3tm1.1Dek/Adcy3tm1.1Dek,Adcy6tm1.1Dek/Adcy6tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0004231 abnormal calcium ion homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of calcium ions within the body or between a cell and its external environment" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0005558 decreased creatinine clearance "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo,Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0005618 decreased potassium excretion "less than the normal amount of this alkaline metallic element, the most abundant intracellular ion, voided by the kidneys" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo,Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adcy6tm2Yich/Adcy6tm2Yich
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Adcy3tm1.1Dek/Adcy3tm1.1Dek,Adcy6tm1.1Dek/Adcy6tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo,Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adcy6tm2Yich/Adcy6tm2Yich
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Adcy3tm1.1Dek/Adcy3tm1.1Dek,Adcy6tm1.1Dek/Adcy6tm1.1Dek,Tg(AQP2-cre)2Dek/0
Genetic Background: involves: 129X1/SvJ * C57BL/6 * CBA

 MP:0010108 abnormal renal water reabsorption "any anomaly in the process by which water is passively transported out of the renal tubules back into the bloodstream" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo,Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adcy6tm2Yich/Adcy6tm2Yich
Genetic Background: involves: 129S6/SvEvTac

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nodaltm1.1Mku/Nodaltm2Mku,Tg(T-cre)1Lwd/0
Genetic Background: involves: 129S1/Sv * C3H * C57BL/6

 MP:0011460 decreased urine chloride ion level "abnormally low amounts of chloride ion in the urine" [MGI:csmith]
Show

Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo,Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adcy6tm2Yich/Adcy6tm2Yich
Genetic Background: involves: 129S6/SvEvTac

 MP:0011467 decreased urine urea nitrogen level "abnormally low amounts of nitrogen in the form of urea in the urine" [MGI:csmith]
Show

Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo,Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adcy6tm2Yich/Adcy6tm2Yich
Genetic Background: involves: 129S6/SvEvTac

 MP:0011471 decreased urine creatinine level "a reduced amount of creatinine in the urine compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Adcy6tm2Yich/Adcy6tm2Yich
Genetic Background: involves: 129S6/SvEvTac

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Hif1atm1Rsjo/Hif1atm1Rsjo,Hif1antm1.2Rsjo/Hif1antm1.2Rsjo
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adcy6tm2Yich/Adcy6tm2Yich
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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