ENSMUSG00000023066


Mus musculus

Features
Gene ID: ENSMUSG00000023066
  
Biological name :Rttn
  
Synonyms : Q8R4Y8 / Rotatin / Rttn
  
Possible biological names infered from orthology : Q86VV8
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E4
Gene start: 88971790
Gene end: 89131013
  
Corresponding Affymetrix probe sets: 10457118 (MoGene1.0st)   1431919_at (Mouse Genome 430 2.0 Array)   1436588_at (Mouse Genome 430 2.0 Array)   1460110_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023828
NCBI entrez gene - 246102     See in Manteia.
MGI - MGI:2179288
RefSeq - XM_011247080
RefSeq - NM_175542
RefSeq - XM_006526477
RefSeq Peptide - NP_780751
swissprot - Q8R4Y8
Ensembl - ENSMUSG00000023066
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rttnENSDARG00000004131Danio rerio
 RTTNENSGALG00000013745Gallus gallus
 RTTNENSG00000176225Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR029249  Rotatin, N-terminal
 IPR030791  Rotatin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0044782 cilium organization IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016021 integral component of membrane ISS
 cellular_componentGO:0036064 ciliary basal body ISO
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004252 abnormal direction of looping morphogenesis "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004712 notochord degeneration "retrogressive pathologic change of the axial fibrocellular cord in embryos around which develops the vertebral primordia (prior to normal differentiation of this tissue into the vertebral column tissues)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cacna1ctm2Hfm/Cacna1ctm2Hfm
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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