ENSMUSG00000023333


Mus musculus

Features
Gene ID: ENSMUSG00000023333
  
Biological name :Gcm1
  
Synonyms : Chorion-specific transcription factor GCMa / Gcm1 / P70348
  
Possible biological names infered from orthology : glial cells missing homolog 1 / Q9NP62
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: E1
Gene start: 78051924
Gene end: 78065624
  
Corresponding Affymetrix probe sets: 10587293 (MoGene1.0st)   1420601_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000024104
NCBI entrez gene - 14531     See in Manteia.
MGI - MGI:108045
RefSeq - NM_008103
RefSeq Peptide - NP_032129
swissprot - P70348
swissprot - Q3UQD1
Ensembl - ENSMUSG00000023333
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GCM1ENSGALG00000016316Gallus gallus
 GCM1ENSG00000137270Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gcm2 / glial cells missing homolog 2 / O75603*ENSMUSG0000002136234


Protein motifs (from Interpro)
Interpro ID Name
 IPR003902  Transcription regulator GCM domain
 IPR036115  GCM domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060018 astrocyte fate commitment IDA
 biological_processGO:0060143 positive regulation of syncytium formation by plasma membrane fusion IMP
 biological_processGO:0060670 branching involved in labyrinthine layer morphogenesis IMP
 biological_processGO:0060706 cell differentiation involved in embryonic placenta development IMP
 biological_processGO:0060800 regulation of cell differentiation involved in embryonic placenta development IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Nthl1tm1Yas/Nthl1tm1Yas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0002080 prenatal lethality "death anytime between fertilization and E18.5" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Esx1tm1Bhr/Y
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Crb1rd8/Crb1rd8
Genetic Background: involves: C3HfB6/Ga * C57BL/6 * CAST/EiJ

 MP:0003403 absent placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:73417]
Show

Allelic Composition: Nthl1tm1Yas/Nthl1tm1Yas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004560 abnormal chorionic plate morphology "any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nthl1tm1Yas/Nthl1tm1Yas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Mybl1repro9/Mybl1tm1Epr
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

Allelic Composition: Gcm1tm1Hoso/Gcm1tm1Hoso,Gcm2tm1Hoso/Gcm2tm1Hoso
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Nthl1tm1Yas/Nthl1tm1Yas
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011097 complete embryonic lethality before turning of embryo "death of all organisms of a given genotype in a population between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: Gcm1tm1Hoso/Gcm1tm1Hoso,Gcm2tm1Hoso/Gcm2tm1Hoso
Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * CD-1)

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Atp2a2tm1Fwuy/Atp2a2tm1Fwuy,Plntm1Egk/Plntm1Egk
Genetic Background: involves: 129 * FVB/N * Swiss

 MP:0011524 thick placenta labyrinth "increase in the width of the structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [MGI:csmith]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0011526 abnormal placenta fetal blood space morphology "any structural anomaly of the spaces of the placenta occupied by fetal blood, primarily within the fetal labyrinth villi" [MGI:csmith]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0011529 increased placenta intervillous maternal lacunae size "increased size of the spaces of the placenta occupied by maternal blood, into which the fetal labyrinth villi project" [MGI:csmith]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0011531 abnormal syncytiotrophoblast morphology "any structural anomaly of the multi-nucleated, terminally differentiated syncytial epithelial layer of the placental villi that forms the major nutrient transport surfaces within the labyrinth layer of the rodent placenta" [ISBN-10:0521851653]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
Show

Allelic Composition: Col2a1Lpk/Col2a1Lpk
Genetic Background: involves: C3H/HeH * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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