ENSMUSG00000023994


Mus musculus

Features
Gene ID: ENSMUSG00000023994
  
Biological name :Nfya
  
Synonyms : Mus musculus nuclear transcription factor-Y alpha (Nfya), transcript variant 3, mRNA. / Nfya / P23708
  
Possible biological names infered from orthology : nuclear transcription factor Y subunit alpha / P23511
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: C
Gene start: 48386885
Gene end: 48409906
  
Corresponding Affymetrix probe sets: 10451650 (MoGene1.0st)   1422082_a_at (Mouse Genome 430 2.0 Array)   1427808_at (Mouse Genome 430 2.0 Array)   1452560_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124501
Ensembl peptide - ENSMUSP00000124404
Ensembl peptide - ENSMUSP00000124965
Ensembl peptide - ENSMUSP00000125034
Ensembl peptide - ENSMUSP00000043909
Ensembl peptide - ENSMUSP00000077853
Ensembl peptide - ENSMUSP00000123785
Ensembl peptide - ENSMUSP00000124115
Ensembl peptide - ENSMUSP00000124245
NCBI entrez gene - 18044     See in Manteia.
MGI - MGI:97316
RefSeq - XM_017317292
RefSeq - NM_001110832
RefSeq - NM_001347401
RefSeq - NM_001347402
RefSeq - NM_010913
RefSeq - XM_006523791
RefSeq - XM_006523793
RefSeq - XM_006523794
RefSeq - XM_006523795
RefSeq - XM_006523796
RefSeq Peptide - NP_001104302
RefSeq Peptide - NP_001334330
RefSeq Peptide - NP_001334331
RefSeq Peptide - NP_035043
swissprot - E0CYF3
swissprot - F6TUY8
swissprot - F6TWX0
swissprot - F7DFJ2
swissprot - E0CY40
swissprot - P23708
swissprot - Q3UP82
swissprot - Q9DBV7
swissprot - A0A0R4J1Y8
Ensembl - ENSMUSG00000023994
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfyaENSDARG00000042004Danio rerio
 nfyalENSDARG00000001621Danio rerio
 NFYAENSGALG00000003247Gallus gallus
 NFYAENSG00000001167Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001289  Nuclear transcription factor Y subunit A
 IPR018362  CCAAT-binding factor, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048511 rhythmic process IEA
 biological_processGO:2000036 regulation of stem cell population maintenance IDA
 biological_processGO:2000648 positive regulation of stem cell proliferation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0016602 CCAAT-binding factor complex IEA
 cellular_componentGO:0032993 protein-DNA complex IEA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IGI
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Cntnap1tm1Pele/Cntnap1tm1Pele
Genetic Background: Not Specified

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: E2f1tm1Njd/E2f1tm1Njd,Rb1tm1Tyj/Rb1+
Genetic Background: either: 129S2/SvPas or (involves: 129S2/SvPas * C57BL/6)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032897 Nfyc / P70353 / Mus musculus nuclear transcription factor-Y gamma (Nfyc), transcript variant 4, mRNA. / Q13952* / nuclear transcription factor Y subunit gamma*  / complex
 ENSMUSG00000020538 Q9WTN3 / Srebf1 / Mus musculus sterol regulatory element binding transcription factor 1 (Srebf1), transcript variant 4, mRNA. / P36956* / sterol regulatory element binding transcription factor 1*  / complex / reaction
 ENSMUSG00000020248 Nfyb / P63139 / Nuclear transcription factor Y subunit beta / P25208*  / complex






 

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