ENSMUSG00000024313


Mus musculus

Features
Gene ID: ENSMUSG00000024313
  
Biological name :Mep1b
  
Synonyms : Mep1b / Meprin A subunit beta / Q61847
  
Possible biological names infered from orthology : Q16820
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: A2
Gene start: 21072344
Gene end: 21100199
  
Corresponding Affymetrix probe sets: 10454212 (MoGene1.0st)   1418215_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000080866
NCBI entrez gene - 17288     See in Manteia.
MGI - MGI:96964
RefSeq - NM_008586
RefSeq Peptide - NP_032612
swissprot - Q61847
Ensembl - ENSMUSG00000024313
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mep1bENSDARG00000037533Danio rerio
 si:ch73-40a17.3ENSDARG00000040683Danio rerio
 MEP1BENSGALG00000044606Gallus gallus
 MEP1BENSG00000141434Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mep1a / P28825 / Meprin A subunit alpha / Q16819*ENSMUSG0000002391441
Astl / Q6HA09 / Astacin-like metalloendopeptidase / Q6HA08*ENSMUSG0000005046816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR000998  MAM domain
 IPR001506  Peptidase M12A
 IPR002083  MATH/TRAF domain
 IPR006026  Peptidase, metallopeptidase
 IPR008294  Meprin alpha/beta subunit
 IPR008974  TRAF-like
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR024079  Metallopeptidase, catalytic domain superfamily
 IPR034302  Meprin beta subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:1901998 toxin transport IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017090 meprin A complex IEA
 molecular_functionGO:0004222 metalloendopeptidase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg
Genetic Background: B6.Cg-Usp46Gt(pU17)1Imeg

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg
Genetic Background: B6.Cg-Usp46Gt(pU17)1Imeg

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg
Genetic Background: B6.Cg-Usp46Gt(pU17)1Imeg

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg
Genetic Background: B6.Cg-Usp46Gt(pU17)1Imeg

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ssfa2tm1Sawa/Ssfa2tm1Sawa
Genetic Background: B6.Cg-Ssfa2tm1Sawa

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg
Genetic Background: B6.Cg-Usp46Gt(pU17)1Imeg

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53tm1Tyj,Tsg101tm1Mak/Tsg101tm1Mak
Genetic Background: involves: 129P3/J * 129S2/SvPas * C57BL/6 * CD-1

 MP:0011352 proximal convoluted tubule brush border loss "attenuation or degeneration of the microvillus brush border normally present on the luminal surface of epithelial cells of the proximal convoluted tubule; may be associated with renal tubular injury and/or cystic changes" [MGI:anna]
Show

Allelic Composition: Usp46Gt(pU17)1Imeg/Usp46Gt(pU17)1Imeg
Genetic Background: B6.Cg-Usp46Gt(pU17)1Imeg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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