ENSMUSG00000024544


Mus musculus

Features
Gene ID: ENSMUSG00000024544
  
Biological name :Ldlrad4
  
Synonyms : Ldlrad4 / Low-density lipoprotein receptor class A domain-containing protein 4 / Q8BWJ4
  
Possible biological names infered from orthology : low density lipoprotein receptor class A domain containing 4 / O15165
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: E2
Gene start: 67933257
Gene end: 68255549
  
Corresponding Affymetrix probe sets: 10456492 (MoGene1.0st)   1427181_at (Mouse Genome 430 2.0 Array)   1427182_s_at (Mouse Genome 430 2.0 Array)   1447662_x_at (Mouse Genome 430 2.0 Array)   1452343_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000068471
NCBI entrez gene - 52662     See in Manteia.
MGI - MGI:1277150
RefSeq - XM_006526089
RefSeq - NM_172631
RefSeq - XM_006526086
RefSeq - XM_006526087
RefSeq - XM_006526088
RefSeq - XM_006526085
RefSeq Peptide - NP_766219
swissprot - Q4VAH9
swissprot - Q8BWJ4
Ensembl - ENSMUSG00000024544
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ldlrad4aENSDARG00000070555Danio rerio
 ldlrad4bENSDARG00000054941Danio rerio
 LDLRAD4ENSGALG00000013886Gallus gallus
 O15165ENSG00000168675Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pmepa1 / prostate transmembrane protein, androgen induced 1 / Q969W9*ENSMUSG0000003840053


Protein motifs (from Interpro)
Interpro ID Name
 IPR002172  Low-density lipoprotein (LDL) receptor class A repeat
 IPR023415  Low-density lipoprotein (LDL) receptor class A, conserved site
 IPR036055  LDL receptor-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009968 negative regulation of signal transduction IEA
 biological_processGO:0010719 negative regulation of epithelial to mesenchymal transition IEA
 biological_processGO:0010991 negative regulation of SMAD protein complex assembly ISS
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0060394 negative regulation of pathway-restricted SMAD protein phosphorylation ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031901 early endosome membrane ISS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

 MP:0008040 decreased NK T cell number "reduced number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
Show

Allelic Composition: Lama1tm2b(EUCOMM)Hmgu/Lama1+
Genetic Background: C57BL/6N-Lama1tm2b(EUCOMM)Hmgu/Ieg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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