| MP:0000087 | absent mandible | "missing the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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| MP:0000111 | cleft palate | "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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| MP:0000439 | enlarged skull | |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0000440 | domed skull | |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0000445 | short snout | "reduced length of the anterior facial part of the muzzle" [J:53370] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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| MP:0000519 | hydronephrosis | "dilation of the pelvis and calices of one or both kidneys" [J:56641] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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| MP:0000914 | exencephaly | "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0000928 | incomplete cephalic closure | "arrest of the fusion of the cephalic neural folds" [J:12622] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0000929 | open neural tube | "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0001293 | anophthalmia | "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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| MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0002151 | abnormal neural tube morphology/development | "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0003052 | omphalocele | "protrusion of abdominal viscera at the base of the umbilical cord, with a covering membranous sac of peritoneum-amnion" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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| MP:0003675 | kidney cysts | "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0004261 | abnormal embryonic neuroepithelium morphology | "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0005170 | cleft lip | "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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| MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0009642 | abnormal blood homeostasis | "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0009643 | abnormal urine homeostasis | "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Tll1b2b2476Clo/Tll1b2b2476Clo
Genetic Background: C57BL/6J-Tll1b2b2476Clo
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0011100 | complete preweaning lethality | "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith] |
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Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J
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| MP:0011230 | abnormal folic acid level | "any anomaly in the concentration of the vitamin B family member that stimulates the hematopoietic system, is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses, and is used in the treatment and prevention of folate deficiencies and megaloblastic anemia" [MESH:D03.438.733.631.400] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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| MP:0011380 | enlarged brain ventricle | "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb] |
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Allelic Composition: Sdcbptm1c(KOMP)Wtsi/Sdcbp+,Tsc2tm1Tno/Tsc2+,Tg(Camk2a-cre)2Gsc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6N * FVB/N
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