ENSMUSG00000024990


Mus musculus

Features
Gene ID: ENSMUSG00000024990
  
Biological name :Rbp4
  
Synonyms : Q00724 / Rbp4 / Retinol-binding protein 4
  
Possible biological names infered from orthology : P02753
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C2
Gene start: 38116620
Gene end: 38125321
  
Corresponding Affymetrix probe sets: 10467319 (MoGene1.0st)   1426225_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025951
Ensembl peptide - ENSMUSP00000107954
NCBI entrez gene - 19662     See in Manteia.
MGI - MGI:97879
RefSeq - NM_001159487
RefSeq - NM_011255
RefSeq Peptide - NP_001152959
RefSeq Peptide - NP_035385
swissprot - Q00724
swissprot - H7BWY6
Ensembl - ENSMUSG00000024990
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbp4ENSDARG00000101199Danio rerio
 RBP4AENSGALG00000006629Gallus gallus
 RBP4ENSG00000138207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000566  Lipocalin/cytosolic fatty-acid binding domain
 IPR002345  Lipocalin
 IPR002449  Retinol binding protein/Purpurin
 IPR012674  Calycin
 IPR022271  Lipocalin, ApoD type
 IPR022272  Lipocalin family conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001654 eye development IMP
 biological_processGO:0006094 gluconeogenesis IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0030277 maintenance of gastrointestinal epithelium ISO
 biological_processGO:0030324 lung development IMP
 biological_processGO:0032024 positive regulation of insulin secretion ISO
 biological_processGO:0032526 response to retinoic acid ISO
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0034633 retinol transport IMP
 biological_processGO:0042572 retinol metabolic process ISO
 biological_processGO:0042574 retinal metabolic process IMP
 biological_processGO:0042593 glucose homeostasis ISO
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0048562 embryonic organ morphogenesis IMP
 biological_processGO:0048706 embryonic skeletal system development IMP
 biological_processGO:0048738 cardiac muscle tissue development IMP
 biological_processGO:0048807 female genitalia morphogenesis IMP
 biological_processGO:0050908 detection of light stimulus involved in visual perception IMP
 biological_processGO:0051024 positive regulation of immunoglobulin secretion IDA
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation IMP
 biological_processGO:0060059 embryonic retina morphogenesis in camera-type eye IMP
 biological_processGO:0060065 uterus development IMP
 biological_processGO:0060068 vagina development IMP
 biological_processGO:0060157 urinary bladder development IMP
 biological_processGO:0060347 heart trabecula formation IMP
 biological_processGO:0071939 vitamin A import IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space ISO
 molecular_functionGO:0005501 retinoid binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016918 retinal binding IEA
 molecular_functionGO:0019841 retinol binding ISO
 molecular_functionGO:0034632 retinol transmembrane transporter activity IEA
 molecular_functionGO:0036094 small molecule binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
The canonical retinoid cycle in rods (twilight vision)
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

 MP:0001539 decreased number of caudal vertebrae "reduced number of the bony segments of the tail" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Rad9atm1.1(KOMP)Wtsi/Rad9atm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Rad9atm1.1(KOMP)Wtsi/Bay

 MP:0001929 abnormal gametogenesis "defective formation or differentiation of germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:42324]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: H6pdtm1Pmst/H6pdtm1Pmst
Genetic Background: involves: 129P2/OlaHsd

 MP:0003567 abnormal cardiomyocyte proliferation "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003698 abnormal male reproductive system physiology "anomaly in the function of the male organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nhlh1tm1Irk/Nhlh1tm1Irk,Nhlh2tm1Irk/Nhlh2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004182 abnormal spermiation "failure of mature spermatozoa to release from supporting Sertoli cells into the lumen of seminiferous tubules" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0005400 abnormal vitamin level "anomalous concentration of any of the organic substances found in food that are necessary in trace amounts for normal metabolic function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Igf1tm1Arge/Igf1tm1Arge,Igf1rtm1Arge/Igf1rtm1Arge
Genetic Background: either: (involves: 129S/SvEv) or (involves: 129S/SvEv * C57BL/6J) or (involves: 129S/SvEv * MF1)

 MP:0011234 abnormal retinol level "any anomaly in the concentration of retinol, which plays an essential role in metabolic functioning of the retina, and growth and differentiation" [ISBN:0-683-40008-8]
Show

Allelic Composition: Stat1tm1Dlv/Stat1tm1Dlv
Genetic Background: B6.129-Stat1tm1Dlv

Allelic Composition: Rbp4tm1.1Mma/Rbp4tm1.1Mma
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Rbp4tm1.1Mma/Rbp4+
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000061808 Ttr / P07309 / transthyretin / P02766*  / complex / reaction






 

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