ENSMUSG00000025269


Mus musculus

Features
Gene ID: ENSMUSG00000025269
  
Biological name :Apex2
  
Synonyms : Apex2 / DNA-(apurinic or apyrimidinic site) lyase 2 / Q68G58
  
Possible biological names infered from orthology : apurinic/apyrimidinic endodeoxyribonuclease 2 / Q9UBZ4
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F3
Gene start: 150519519
Gene end: 150589868
  
Corresponding Affymetrix probe sets: 10607250 (MoGene1.0st)   1424322_at (Mouse Genome 430 2.0 Array)   1425954_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108341
Ensembl peptide - ENSMUSP00000122554
Ensembl peptide - ENSMUSP00000108347
Ensembl peptide - ENSMUSP00000108345
Ensembl peptide - ENSMUSP00000026303
Ensembl peptide - ENSMUSP00000108339
Ensembl peptide - ENSMUSP00000108340
NCBI entrez gene - 77622     See in Manteia.
MGI - MGI:1924872
RefSeq - XM_011247880
RefSeq - XM_011247879
RefSeq - XM_006528991
RefSeq - NM_029943
RefSeq - XM_011247877
RefSeq - XM_011247878
RefSeq Peptide - NP_084219
swissprot - Q68G58
swissprot - A2AFM5
swissprot - F7CPY7
swissprot - A2AFM3
swissprot - A2AFM4
Ensembl - ENSMUSG00000025269
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apex2ENSDARG00000008472Danio rerio
 APEX2ENSG00000169188Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Apex1 / P28352 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1*ENSMUSG0000003596016


Protein motifs (from Interpro)
Interpro ID Name
 IPR004808  AP endonuclease 1
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR010666  Zinc finger, GRF-type
 IPR020847  AP endonuclease 1, binding site
 IPR036691  Endonuclease/exonuclease/phosphatase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IBA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005743 mitochondrial inner membrane IDA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004527 exonuclease activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008311 double-stranded DNA 3"-5" exodeoxyribonuclease activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0002879 increased sensitivity to X-ray irradiation "increased incidence of cell death following high levels of X-ray irradiation" [RGD:Rat Genome Database submission]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0003644 thymus atrophy "wasting of the thymus resulting in reduced size " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0009674 decreased birth weight "reduction in average weight at birth compared to controls" [RGD:cur "Rat Genome Database submission"]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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