ENSDARG00000008472


Danio rerio

Features
Gene ID: ENSDARG00000008472
  
Biological name :apex2
  
Synonyms : apex2 / APEX nuclease (apurinic/apyrimidinic endonuclease) 2
  
Possible biological names infered from orthology : apurinic/apyrimidinic endodeoxyribonuclease 2 / DNA-(apurinic or apyrimidinic site) lyase 2 / Q68G58 / Q9UBZ4
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 22509508
Gene end: 22515042
  
Corresponding Affymetrix probe sets: Dr.20924.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000021896
Ensembl peptide - ENSDARP00000149485
NCBI entrez gene - 393115     See in Manteia.
RefSeq - NM_200146
RefSeq Peptide - NP_956440
swissprot - F1Q865
ZFIN ID - ZDB-GENE-040426-835
Ensembl - ENSDARG00000008472
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APEX2ENSG00000169188Homo sapiens
 Apex2ENSMUSG00000025269Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
apex1 / APEX nuclease (multifunctional DNA repair enzyme) 1 / P28352* / P27695* / apurinic/apyrimidinic endodeoxyribonuclease 1* / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or...ENSDARG0000004584314


Protein motifs (from Interpro)
Interpro ID Name
 IPR004808  AP endonuclease 1
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR010666  Zinc finger, GRF-type
 IPR020847  AP endonuclease 1, binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006284 base-excision repair IBA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IBA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0008311 double-stranded DNA 3"-5" exodeoxyribonuclease activity IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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