ENSDARG00000045843


Danio rerio

Features
Gene ID: ENSDARG00000045843
  
Biological name :apex1
  
Synonyms : apex1 / APEX nuclease (multifunctional DNA repair enzyme) 1
  
Possible biological names infered from orthology : apurinic/apyrimidinic endodeoxyribonuclease 1 / DNA-(apurinic or apyrimidinic site) lyase DNA-(apurinic or apyrimidinic site) lyase, mitochondrial / P27695 / P28352
  
Species: Danio rerio
  
Chr. number: 4
Strand: 1
Band:
Gene start: 5333988
Gene end: 5340530
  
Corresponding Affymetrix probe sets: Dr.20170.2.A1_at (Zebrafish Array)   NM_213421_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000138791
Ensembl peptide - ENSDARP00000067373
Ensembl peptide - ENSDARP00000110718
Ensembl peptide - ENSDARP00000125428
Ensembl peptide - ENSDARP00000125398
Ensembl peptide - ENSDARP00000125208
Ensembl peptide - ENSDARP00000156404
Ensembl peptide - ENSDARP00000125549
Ensembl peptide - ENSDARP00000125593
NCBI entrez gene - 406730     See in Manteia.
RefSeq - NM_001328578
RefSeq - NM_001328580
RefSeq - NM_213421
RefSeq - NM_001328579
RefSeq Peptide - NP_001315509
RefSeq Peptide - NP_001315508
RefSeq Peptide - NP_001315507
RefSeq Peptide - NP_998586
swissprot - H0WEW8
swissprot - A0A0R4IWF9
swissprot - F1QTR9
swissprot - H0WED1
swissprot - H0WEZ7
swissprot - H0WFB7
swissprot - H0WFG1
ZFIN ID - ZDB-GENE-040426-2761
Ensembl - ENSDARG00000045843
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APEX1ENSG00000100823Homo sapiens
 Apex1ENSMUSG00000035960Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
apex2 / APEX nuclease (apurinic/apyrimidinic endonuclease) 2 / Q68G58* / Q9UBZ4* / DNA-(apurinic or apyrimidinic site) lyase 2 * / apurinic/apyrimidinic endodeoxyribonuclease 2*ENSDARG0000000847225


Protein motifs (from Interpro)
Interpro ID Name
 IPR004808  AP endonuclease 1
 IPR005135  Endonuclease/exonuclease/phosphatase
 IPR020847  AP endonuclease 1, binding site
 IPR020848  AP endonuclease 1, conserved site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity IEA
 molecular_functionGO:0140080 class III/IV DNA-(apurinic or apyrimidinic site) endonuclease activity IEA


Pathways (from Reactome)
Pathway description
Displacement of DNA glycosylase by APEX1
POLB-Dependent Long Patch Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
PCNA-Dependent Long Patch Base Excision Repair
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Resolution of Abasic Sites (AP sites)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain deformed , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart deformed , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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