ENSMUSG00000025588


Mus musculus

Features
Gene ID: ENSMUSG00000025588
  
Biological name :Nat1
  
Synonyms : N-acetyl transferase 1 / Nat1 / P50294
  
Possible biological names infered from orthology : N-acetyltransferase 1 / N-acetyltransferase 2 / NAT2 / P11245 / P18440
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.2
Gene start: 67480921
Gene end: 67492104
  
Corresponding Affymetrix probe sets: 10572085 (MoGene1.0st)   1421758_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148354
Ensembl peptide - ENSMUSP00000026677
NCBI entrez gene - 17960     See in Manteia.
MGI - MGI:97279
RefSeq - NM_008673
RefSeq Peptide - NP_032699
swissprot - A0A1D5RLG2
swissprot - P50294
swissprot - Q546L3
Ensembl - ENSMUSG00000025588
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-78a14.4ENSDARG00000036066Danio rerio
 zgc:101040ENSDARG00000005176Danio rerio
 NATENSGALG00000005472Gallus gallus
 PNAT10ENSGALG00000005474Gallus gallus
 PNAT3ENSGALG00000005473Gallus gallus
 NAT1ENSG00000171428Homo sapiens
 NAT2ENSG00000156006Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nat2 / P50295 / N-acetyltransferase 2 (arylamine N-acetyltransferase) / NAT1* / P11245* / P18440* / N-acetyltransferase 2* / N-acetyltransferase 1*ENSMUSG0000005114782
Nat3 / P50296 / N-acetyltransferase 3 / NAT1* / NAT2* / P18440* / P11245* / N-acetyltransferase 2* / N-acetyltransferase 1*ENSMUSG0000005642668


Protein motifs (from Interpro)
Interpro ID Name
 IPR001447  Arylamine N-acetyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0097068 response to thyroxine IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0004060 arylamine N-acetyltransferase activity IEA
 molecular_functionGO:0016407 acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Acetylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fzd5tm1Nat/Fzd5tm2Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

Allelic Composition: Nat1Rgsc1523/Nat1+
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli2tm1Alj/Gli2+,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

 MP:0011396 abnormal sleep behavior "any anomaly in the actions, reactions, or performance of an organism during a periodic, readily reversible state of reduced awareness and metabolic activity" [MGI:smb]
Show

Allelic Composition: Nampttm1.1(KOMP)Vlcg/Nampttm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nampttm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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