ENSMUSG00000051147


Mus musculus

Features
Gene ID: ENSMUSG00000051147
  
Biological name :Nat2
  
Synonyms : N-acetyltransferase 2 (arylamine N-acetyltransferase) / Nat2 / P50295
  
Possible biological names infered from orthology : N-acetyltransferase 1 / N-acetyltransferase 2 / NAT1 / P11245 / P18440
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: B3.2
Gene start: 67494858
Gene end: 67502584
  
Corresponding Affymetrix probe sets: 10572089 (MoGene1.0st)   1449981_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091181
Ensembl peptide - ENSMUSP00000130065
NCBI entrez gene - 17961     See in Manteia.
MGI - MGI:109201
RefSeq - NM_010874
RefSeq - NM_001168577
RefSeq Peptide - NP_001162049
RefSeq Peptide - NP_035004
swissprot - P50295
swissprot - Q78ZC4
Ensembl - ENSMUSG00000051147
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkey-78a14.4ENSDARG00000036066Danio rerio
 zgc:101040ENSDARG00000005176Danio rerio
 NATENSGALG00000005472Gallus gallus
 PNAT10ENSGALG00000005474Gallus gallus
 PNAT3ENSGALG00000005473Gallus gallus
 NAT1ENSG00000171428Homo sapiens
 NAT2ENSG00000156006Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nat1 / P50294 / N-acetyl transferase 1 / NAT2* / P11245* / P18440* / N-acetyltransferase 1* / N-acetyltransferase 2*ENSMUSG0000002558882
Nat3 / P50296 / N-acetyltransferase 3 / NAT1* / NAT2* / P18440* / P11245* / N-acetyltransferase 2* / N-acetyltransferase 1*ENSMUSG0000005642673


Protein motifs (from Interpro)
Interpro ID Name
 IPR001447  Arylamine N-acetyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004060 arylamine N-acetyltransferase activity IEA
 molecular_functionGO:0016407 acetyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA


Pathways (from Reactome)
Pathway description
Acetylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001293 anophthalmia "congenital absence of all tissues of the eyes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CML, J:71979]
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Allelic Composition: Slc40a1tm2Nca/Slc40a1tm2Nca,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
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Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0002092 abnormal eye morphology "abnormal development of the eye tissues resulting in morphological abnormality or abnormal structure of the visual system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Anktm1Kng/Ank+,Tg(Gdf5-cre-ALPP)1Kng/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003078 aphakia "absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nat2tm1Esim/Nat2+
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Slc40a1tm2Nca/Slc40a1tm2Nca,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004179 transmission ratio distortion "the occurence of an allele or haplotype in the offspring of an organism at skewed Mendelian ratios" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: involves: 129P2/OlaHsd * A/J

Allelic Composition: Nat2tm1Esim/Nat2tm1Esim
Genetic Background: A.129P2-Nat2tm1Esim

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Slc40a1tm2Nca/Slc40a1tm2Nca,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gli2tm1Alj/Gli2+,Gli3Xt-J/Gli3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C3H * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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