ENSMUSG00000025855


Mus musculus

Features
Gene ID: ENSMUSG00000025855
  
Biological name :Prkar1b
  
Synonyms : P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta
  
Possible biological names infered from orthology : P31321 / protein kinase cAMP-dependent type I regulatory subunit beta
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 139017306
Gene end: 139150001
  
Corresponding Affymetrix probe sets: 10535053 (MoGene1.0st)   1416753_at (Mouse Genome 430 2.0 Array)   1416754_at (Mouse Genome 430 2.0 Array)   1434325_x_at (Mouse Genome 430 2.0 Array)   1440132_s_at (Mouse Genome 430 2.0 Array)   1440133_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106514
Ensembl peptide - ENSMUSP00000106515
Ensembl peptide - ENSMUSP00000123286
Ensembl peptide - ENSMUSP00000122693
Ensembl peptide - ENSMUSP00000121093
Ensembl peptide - ENSMUSP00000117412
Ensembl peptide - ENSMUSP00000116727
Ensembl peptide - ENSMUSP00000116022
Ensembl peptide - ENSMUSP00000026973
NCBI entrez gene - 19085     See in Manteia.
MGI - MGI:97759
RefSeq - XM_017320719
RefSeq - NM_001253890
RefSeq - NM_001359097
RefSeq - NM_001359098
RefSeq - NM_001359099
RefSeq - NM_001359100
RefSeq - NM_008923
RefSeq - XM_006504660
RefSeq - XM_006504661
RefSeq - XM_006504663
RefSeq Peptide - NP_032949
RefSeq Peptide - NP_001240819
RefSeq Peptide - NP_001346026
RefSeq Peptide - NP_001346027
RefSeq Peptide - NP_001346028
RefSeq Peptide - NP_001346029
swissprot - D3Z4A5
swissprot - D3Z406
swissprot - D3Z0V6
swissprot - P12849
swissprot - D3Z7E4
swissprot - D3Z068
swissprot - D3YTM5
swissprot - D3Z4L4
Ensembl - ENSMUSG00000025855
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prkar1bENSDARG00000103800Danio rerio
 PRKAR1BENSGALG00000003675Gallus gallus
 P31321ENSG00000188191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*ENSMUSG0000002061282
P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*ENSMUSG0000000299738
Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*ENSMUSG0000003260138


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003117  cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
 IPR012198  cAMP-dependent protein kinase regulatory subunit
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0045859 regulation of protein kinase activity IEA
 biological_processGO:2000480 negative regulation of cAMP-dependent protein kinase activity ISO
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005952 cAMP-dependent protein kinase complex IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004862 cAMP-dependent protein kinase inhibitor activity ISO
 molecular_functionGO:0008603 cAMP-dependent protein kinase regulator activity IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0034236 protein kinase A catalytic subunit binding ISO


Pathways (from Reactome)
Pathway description
PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog off state
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001473 reduced long term potentiation "less than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001475 reduced long term depression "less than the normal, persistent activity-dependent decrease in synaptic efficacy between neurons, often following slow, weak stimulation of CA1 neurons" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Principles of Neural Science:ISBN 0-8385-8034-3]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0001973 increased thermal nociceptive threshold "a greater than average point at which thermal pain sensation is first detectable" [What s Wrong With My Mouse?:ISBN 0-471-31639-3, J:17194]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

 MP:0002736 abnormal nociception after inflammation "changes in pain thresholds after inflammation" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Oca2p-s/Oca2p-s
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002997 P31324 / Prkar2b / protein kinase, cAMP dependent regulatory, type II beta / P31323* / protein kinase cAMP-dependent type II regulatory subunit beta*  / complex
 ENSMUSG00000018428 Akap1 / O08715 / A-kinase anchor protein 1, mitochondrial / Q92667* / A-kinase anchoring protein 1*  / complex / reaction
 ENSMUSG00000005469 P05132 / Prkaca / protein kinase, cAMP dependent, catalytic, alpha / P17612* / protein kinase cAMP-activated catalytic subunit alpha*  / complex
 ENSMUSG00000005034 P68181 / Prkacb / protein kinase, cAMP dependent, catalytic, beta / P22694* / protein kinase cAMP-activated catalytic subunit beta*  / complex
 ENSMUSG00000025855 P12849 / Prkar1b / protein kinase, cAMP dependent regulatory, type I beta / P31321* / protein kinase cAMP-dependent type I regulatory subunit beta*  / complex
 ENSMUSG00000032601 Prkar2a / protein kinase, cAMP dependent regulatory, type II alpha / P13861* / protein kinase cAMP-dependent type II regulatory subunit alpha*  / complex
 ENSMUSG00000020612 Q9DBC7 / Prkar1a / protein kinase, cAMP dependent regulatory, type I, alpha / P10644* / protein kinase cAMP-dependent type I regulatory subunit alpha*  / complex
 ENSMUSG00000047804 Akap10 / O88845 / A-kinase anchor protein 10, mitochondrial / O43572* / A-kinase anchoring protein 10*  / complex / reaction






 

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