ENSMUSG00000025929


Mus musculus

Features
Gene ID: ENSMUSG00000025929
  
Biological name :Il17a
  
Synonyms : Il17a / Interleukin-17A / Q62386
  
Possible biological names infered from orthology : Q16552
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: A4
Gene start: 20730905
Gene end: 20734496
  
Corresponding Affymetrix probe sets: 10345032 (MoGene1.0st)   1421672_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027061
NCBI entrez gene - 16171     See in Manteia.
MGI - MGI:107364
RefSeq - NM_010552
RefSeq Peptide - NP_034682
swissprot - Q544E6
swissprot - Q62386
Ensembl - ENSMUSG00000025929
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 il17a/f1ENSDARG00000043933Danio rerio
 il17a/f3ENSDARG00000041976Danio rerio
 ENSGALG00000016677Gallus gallus
 IL17AENSGALG00000016678Gallus gallus
 IL17AENSG00000112115Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Il17f / Q7TNI7 / Interleukin-17F / Q96PD4*ENSMUSG0000004187247


Protein motifs (from Interpro)
Interpro ID Name
 IPR010345  Interleukin-17 family
 IPR020440  Interleukin-17, chordata
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0032747 positive regulation of interleukin-23 production IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050832 defense response to fungus IMP
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0072537 fibroblast activation ISO
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IGI
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 molecular_functionGO:0005125 cytokine activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-17 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0000623 reduced salivation "decrease flow, secretion, or amount of saliva" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Opn4tm1Skay/Opn4tm1Skay
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001866 nasal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the proximal portion of the respiratory passages " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002435 abnormal effector T cell morphology/development "anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(LDLR/avidin)Svo/Gt(ROSA)26Sortm1(LDLR/avidin)Svo
Genetic Background: involves: 129/Sv

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

 MP:0002492 decreased IgE "less than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Opn4tm1Skay/Opn4tm1Skay
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0002742 enlarged submandibular lymph nodes "increased size of the submandibular lymph nodes" [J:69405, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003436 resistance to induced arthritis "less likely to be striken with changes in the synovial membranes and thickening of articular structures, widespread degeneration of the collagen fibers in connective tissues, and by atrophy and rarefaction of bony structures that are induced by inflammatory responses caused by chemical or mechanical agents" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:75303]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Il1rntm1Yiw/Il1rntm1Yiw,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

 MP:0003561 rheumatoid arthritis "an autoimmune disease that causes chronic inflammation of the joints and may also cause inflammation of the tissue around the joints, as well as other organs in the body" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

 MP:0003747 mouth mucosal ulceration "lesions through the mucous membrane of the mouth" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

 MP:0004762 increased anti-double stranded DNA antibody level "increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004794 increased anti-nuclear antigen antibody level "elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Opn4tm1Skay/Opn4tm1Skay
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0004802 decreased susceptibility to systemic lupus erythematosus "reduced likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gt(ROSA)26Sortm1(LDLR/avidin)Svo/Gt(ROSA)26Sortm1(LDLR/avidin)Svo
Genetic Background: involves: 129/Sv

 MP:0005350 increased susceptibility to autoimmune disorders "greater likelihood that an organism will develop disease characterized by production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Plekhm2tm1a(EUCOMM)Wtsi/Plekhm2tm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Opn4tm1Skay/Opn4tm1Skay
Genetic Background: involves: 129S1/SvImJ * C57BL/6

 MP:0008097 increased plasma cell number "greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008346 increased gamma-delta T cell number "greater number of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Il17a/Il17ftm1.1Impr/Il17a/Il17ftm1.1Impr
Genetic Background: involves: C57BL/6

 MP:0008348 absent gamma-delta T cells "absence of immature or mature T cells expressing an gamma-delta T cell receptor complex" [CL:0000798, ISBN:0781735149]
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Allelic Composition: Il17a/Il17ftm1.1Impr/Il17a/Il17ftm1.1Impr
Genetic Background: involves: C57BL/6

 MP:0008481 increased spleen germinal center number "greater number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm1Yiw/Il17ftm1Yiw,Il1rntm1Yiw/Il1rntm1Yiw
Genetic Background: involves: 129 * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Cdkn1atm1Led/Cdkn1atm1Led,Hus1tm1Led/Hus1tm1Led
Genetic Background: involves: 129S6/SvEvTac

 MP:0008682 decreased interleukin-17 secretion "reduction in the production or release of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
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Allelic Composition: Il17atm1Cdon/Il17atm1Cdon
Genetic Background: involves: C57BL/6

Allelic Composition: Il17a/Il17ftm1.1Impr/Il17a/Il17ftm1.1Impr
Genetic Background: involves: C57BL/6

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * BALB/cA * C57BL/6J

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17a+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Fcgr2btm1Ttk/Fcgr2btm1Ttk,Il17atm1Yiw/Il17atm1Yiw
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il22tm1Flv/Il22tm1Flv
Genetic Background: involves: 129/Sv * 129P2/OlaHsd * C57BL/6

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gt(ROSA)26Sortm3.1(CAG-Il17a)Awai/Gt(ROSA)26Sor+
Genetic Background: involves: BALB/c * C57BL/6

 MP:0009787 increased susceptibility to infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Il17atm1Yiw/Il17atm1Yiw,Il17ftm2Yiw/Il17ftm2Yiw
Genetic Background: B6.129P2-Il17atm1Yiw Il17ftm2Yiw

Allelic Composition: Il17atm1Yiw/Il17atm1Yiw
Genetic Background: B6.129P2-Il17atm1Yiw

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000002897 Il17ra / Q60943 / Interleukin-17 receptor A / Q96F46*  / complex
 ENSMUSG00000025929 Il17a / Q62386 / Interleukin-17A / Q16552*  / complex
 ENSMUSG00000041872 Il17f / Q7TNI7 / Interleukin-17F / Q96PD4*  / complex
 ENSMUSG00000030281 Il17rc / Q8K4C2 / Interleukin-17 receptor C / Q8NAC3*  / complex






 

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