ENSMUSG00000026000


Mus musculus

Features
Gene ID: ENSMUSG00000026000
  
Biological name :Lancl1
  
Synonyms : Lancl1 / LanC-like protein 1 / O89112
  
Possible biological names infered from orthology : LanC like 1 / O43813
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: C3
Gene start: 67000517
Gene end: 67038872
  
Corresponding Affymetrix probe sets: 10355266 (MoGene1.0st)   1427011_a_at (Mouse Genome 430 2.0 Array)   1427012_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027149
Ensembl peptide - ENSMUSP00000109612
Ensembl peptide - ENSMUSP00000113080
Ensembl peptide - ENSMUSP00000122752
NCBI entrez gene - 14768     See in Manteia.
MGI - MGI:1336997
RefSeq - XM_011238435
RefSeq - NM_001190984
RefSeq - NM_001190985
RefSeq - NM_021295
RefSeq Peptide - NP_001177913
RefSeq Peptide - NP_001177914
RefSeq Peptide - NP_067270
swissprot - O89112
swissprot - B2KGR2
Ensembl - ENSMUSG00000026000
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lancl1ENSDARG00000013741Danio rerio
 LANCL1ENSGALG00000002921Gallus gallus
 LANCL1ENSG00000115365Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lancl2 / Q9JJK2 / LanC-like protein 2 / Q9NS86* / LanC like 2*ENSMUSG0000006219057
Lancl3 / Q8CD19 / LanC-like protein 3 / Q6ZV70* / LanC like 3*ENSMUSG0000004734435


Protein motifs (from Interpro)
Interpro ID Name
 IPR007822  Lanthionine synthetase C-like
 IPR020464  LanC-like protein, eukaryotic


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008270 zinc ion binding ISS
 molecular_functionGO:0017124 SH3 domain binding ISO
 molecular_functionGO:0043295 glutathione binding ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050750 low-density lipoprotein particle receptor binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: F13a1tm1Akic/F13a1tm1Akic
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rp2Gt(EUCJ0183f04)Hmgu/Rp2Gt(EUCJ0183f04)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Lancl1em1Vdd/Lancl1em1Vdd,Lancl2em1Vdd/Lancl2em1Vdd,Lancl3em1Vdd/Lancl3em1Vdd
Genetic Background: FVB/N-Lancl1em1Vdd Lancl2em1Vdd Lancl3em1Vdd

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: F13a1tm1Akic/F13a1tm1Akic
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: F13a1tm1Akic/F13a1tm1Akic
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: F13a1tm1Akic/F13a1tm1Akic
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0006036 abnormal mitochondrial physiology 
Show

Allelic Composition: F13a1tm1Akic/F13a1tm1Akic
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0008235 increased susceptibility to neuronal excitotoxicity "greater than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: F13a1tm1Akic/F13a1tm1Akic
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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