| MP:0000267 | abnormal cardiac development | "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
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| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
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| MP:0000531 | right pulmonary isomerism | "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo
Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0000542 | left-sided isomerism | "the relative symmetry of the organs of the thorax and abdomen as indicated by both atria displaying the morphology of the left atrium" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0000644 | dextrocardia | "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
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| MP:0000650 | mesocardia | "cardiac apex pointing to the middle as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo
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| MP:0000690 | absent spleen | "missing organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:55583] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0000692 | small spleen | "decreased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
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| MP:0000694 | spleen hypoplasia | "small size due to reduced cell number in the spleen" [J:43971] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0001706 | abnormal left-right axis patterning | "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1.1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0002766 | situs inversus | "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
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| MP:0003342 | accessory spleen | "the splenic tissue is divided into equal masses; often related to situs inversus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0004110 | transposition of great arteries | "cardiovascular malformation in which the aorta arises from the right ventricle while the pulmonary artery arises from the left ventricle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo
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| MP:0004113 | abnormal aortic arch morphology | "structural anomoly of the portion of the descending aorta proceeding from the arch of the aorta and extending to the diaphragm " [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0004133 | heterotaxia | "abnormal arrangement of organs or parts of the body in relation to each other" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo
Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0004158 | right aortic arch | "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
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| MP:0004190 | abnormal direction of embryo turning | "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"] |
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Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
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| MP:0004252 | abnormal direction of looping morphogenesis | "deviation from the normal rightward direction of cardiac looping" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
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| MP:0006063 | abnormal inferior vena cava morphology | "structural malformation in the principal vein draining blood from the lower portion of the body" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99] |
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Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo
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| MP:0006113 | abnormal heart septum morphology | "abnormality in the wall between the atria or ventricles of the heart, usually incomplete closure" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0010403 | atrial septal defect | "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375] |
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Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
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| MP:0010406 | absent atrial septum | "absence of the thin membranous structure between the two heart atria" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0010412 | atrioventricular septal defect | "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0010413 | complete atrioventricular septal defect | "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com] |
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Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo
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| MP:0010420 | muscular ventricular septal defect | "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0010422 | heart right ventricle hypoplasia | "underdevelopment or reduced size of the heart right ventricle, often due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0010426 | abnormal heart and great artery attachment | "any anomaly in the in the position or pattern of the connection site of the heart to any of the great arteries, including the pulmonary artery and aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
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| MP:0010443 | total anomalous pulmonary venous connection, intracardiac | "the pulmonary veins connect directly to the right side of heart (eg, coronary sinus or directly to the right atrium) instead of the left atrium" [http://emedicine.medscape.com] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0010454 | abnormal truncus arteriosis septation | "anomaly in the process of dividing the common arterial trunk arising out of both heart ventricles to divide into the aorta and pulmonary artery during development" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
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| MP:0010466 | vascular ring | "the trachea and esophagus are completely encircled by connected segments of the aortic arch and its branches" [http://emedicine.medscape.com] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0010487 | abnormal right subclavian artery morphology | "any structural anomaly of the artery that normally extends from the brachiocephalic artery to the right side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0010808 | right-sided stomach | "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
Allelic Composition: Cfc1b2b970Clo/Cfc1b2b970Clo
Genetic Background: C57BL/6J-Cfc1b2b970Clo
Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Prrxl1tm1And/Prrxl1tm1And
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1
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| MP:0011086 | partial postnatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
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| MP:0011254 | superior-inferior ventricles | "an abnormality in which the heart ventricles are in a superior-inferior relationship due to abnormal displacement of the ventricular mass along the horizontal plane of its long axis; this frequently occurs together with criss-cross atrio-ventricular relationships" [ISBN:0-683-40008-8, MGI:csmith] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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| MP:0011569 | abnormal azygos vein morphology | "any structural anomaly of the unpaired vein which in humans arises from the right ascending lumbar vein or the vena cava, enters the thorax through the aortic orifice in the diaphragm, and terminates in the superior vena cava; unlike humans, mice have a single and left-sided azygos vein that develops from the paired embryonic cardinal venous system and drains most of the right and left thoracic walls into the left anterior vena cava" [MGI:anna] |
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Allelic Composition: Cfc1tm1Mms/Cfc1tm1Mms
Genetic Background: either: (involves: 129S6/SvEvTac * Black Swiss) or (involves: 129S6/SvEvTac * C57BL/6J)
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| MP:0011665 | d-loop transposition of the great arteries | "complete transposition of the great arteries; the d- refers to the dextroposition of the bulboventricular loop (ie, the position of the right ventricle, which is on the right side); in addition, the aorta also tends to be on the right and anterior, and the great arteries are parallel rather than crossing" [PMID:17159076] |
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Allelic Composition: Cfc1b2b2736.1Clo/Cfc1b2b2736.1Clo
Genetic Background: C57BL/6J-Cfc1b2b2736.1Clo
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