ENSMUSG00000026424


Mus musculus

Features
Gene ID: ENSMUSG00000026424
  
Biological name :Gpr37l1
  
Synonyms : Gpr37l1 / G protein-coupled receptor 37-like 1 / Q99JG2
  
Possible biological names infered from orthology : O60883
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 135160234
Gene end: 135167681
  
Corresponding Affymetrix probe sets: 10358023 (MoGene1.0st)   1424146_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027682
NCBI entrez gene - 171469     See in Manteia.
MGI - MGI:1928503
RefSeq - NM_134438
RefSeq Peptide - NP_602320
swissprot - Q99JG2
Ensembl - ENSMUSG00000026424
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpr37l1aENSDARG00000006079Danio rerio
 gpr37l1bENSDARG00000056774Danio rerio
 GPR37L1ENSGALG00000000607Gallus gallus
 O60883ENSG00000170075Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpr37 / Q9QY42 / Prosaposin receptor GPR37 / O15354* / G protein-coupled receptor 37*ENSMUSG0000003990444
Ednrb / P48302 / Endothelin receptor type B / P24530*ENSMUSG0000002212221
Ednra / Q61614 / Endothelin-1 receptor / P25101* / endothelin receptor type A*ENSMUSG0000003161619
Grpr / P21729 / Gastrin-releasing peptide receptor / P30550*ENSMUSG0000003136416
Nmbr / O54799 / Neuromedin-B receptor / P28336*ENSMUSG0000001986515
Brs3 / O54798 / Bombesin receptor subtype-3 / P32247*ENSMUSG0000003113015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR003909  G protein-coupled receptor 37 orphan
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0021940 positive regulation of cerebellar granule cell precursor proliferation IMP
 biological_processGO:0043410 positive regulation of MAPK cascade IEA
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045879 negative regulation of smoothened signaling pathway IMP
 biological_processGO:0048712 negative regulation of astrocyte differentiation IMP
 biological_processGO:1903206 negative regulation of hydrogen peroxide-induced cell death IMP
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IEA
 molecular_functionGO:0036505 prosaposin receptor activity IEA
 molecular_functionGO:0042277 peptide binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000873 thin external granule cell layer "reduced thickness of the transient layer of the cerebellar cortex which is composed of dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tbx4tm1Pa/Tbx4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003153 early eyelid opening "early average time for the first postnatal eye opening" [J:92240, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003313 abnormal locomotor activation "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0003858 enhanced coordination "improved ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0006143 increased diastolic blood pressure "abnormal increase in the pressure in the arteries between heart beats when the heart is relaxed" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

Allelic Composition: Gpr37l1tm1d(EUCOMM)Wtsi/Gpr37l1+
Genetic Background: involves: BALB/cJ * C57BL/6N * SJL

 MP:0006265 increased pulse pressure "increase in the difference between systolic and diastolic blood pressure" [RGD:Rat Genome Database submission]
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Allelic Composition: Daam1tm1.1Tpy/Daam1tm1.1Tpy,Nkx2-5tm1(cre)Rjs/Nkx2-5+,Wnt5atm1Amc/Wnt5atm1Amc
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd

 MP:0008579 abnormal Purkinje cell differentiation "atypical production of or inability to produce the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition"]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0009956 abnormal cerebellar layer morphology "any structural anomaly of the laminar structure of the cerebellar cortex comprising the gray matter of the cerebellum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0010388 abnormal Bergmann glial cell differentiation "abnormal formation of the astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpr37l1tm1.1Gtva/Gpr37l1tm1.1Gtva
Genetic Background: involves: 129S/SvEv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000004207 Psap / Q61207 / prosaposin / P07602*  / complex / reaction






 

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