ENSMUSG00000031364


Mus musculus

Features
Gene ID: ENSMUSG00000031364
  
Biological name :Grpr
  
Synonyms : Gastrin-releasing peptide receptor / Grpr / P21729
  
Possible biological names infered from orthology : P30550
  
Species: Mus musculus
  
Chr. number: X
Strand: -1
Band: F4
Gene start: 163513904
Gene end: 163549677
  
Corresponding Affymetrix probe sets: 10607712 (MoGene1.0st)   1421470_at (Mouse Genome 430 2.0 Array)   1450260_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033730
NCBI entrez gene - 14829     See in Manteia.
MGI - MGI:95836
RefSeq - NM_008177
RefSeq Peptide - NP_032203
swissprot - P21729
Ensembl - ENSMUSG00000031364
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 grprENSDARG00000056620Danio rerio
 GRPRENSGALG00000027960Gallus gallus
 GRPRENSG00000126010Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nmbr / O54799 / Neuromedin-B receptor / P28336*ENSMUSG0000001986556
Brs3 / O54798 / Bombesin receptor subtype-3 / P32247*ENSMUSG0000003113049
Ednrb / P48302 / Endothelin receptor type B / P24530*ENSMUSG0000002212230
Ednra / Q61614 / Endothelin-1 receptor / P25101* / endothelin receptor type A*ENSMUSG0000003161628
Gpr37 / Q9QY42 / Prosaposin receptor GPR37 / O15354* / G protein-coupled receptor 37*ENSMUSG0000003990423
Q99JG2 / Gpr37l1 / G protein-coupled receptor 37-like 1 / O60883*ENSMUSG0000002642420


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001556  Bombesin receptor-like
 IPR001966  Gastrin-releasing peptide receptor
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IMP
 biological_processGO:0007218 neuropeptide signaling pathway IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0031989 bombesin receptor signaling pathway IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0036343 psychomotor behavior IMP
 biological_processGO:0042127 regulation of cell proliferation IMP
 biological_processGO:0043207 response to external biotic stimulus IMP
 biological_processGO:0061744 motor behavior IMP
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004946 bombesin receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008188 neuropeptide receptor activity IMP
 molecular_functionGO:0008528 G-protein coupled peptide receptor activity IDA
 molecular_functionGO:0042923 neuropeptide binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0001412 excessive scratching "compulsive scraping of the skin, usually with the nails" [J:61340]
Show

Allelic Composition: Grprtm1Jfb/Grprtm1Jfb,Slc17a6tm1Kldr/Slc17a6tm1Kldr,Thtm1(cre)Te/Th+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.3Mrt
Genetic Background: involves: 129P2/OlaHsd

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1Schm/Drd2tm1Schm,Drd3tm1Schm/Drd3tm1Schm
Genetic Background: B6.Cg-Drd2tm1Schm Drd3tm1Schm

 MP:0005449 abnormal food intake "anomalous total number of calories taken in daily when compared to the norm" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgf8tm1.2Mrt/Fgf8tm1.3Mrt
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024517 Grp / Q8R1I2 / Gastrin-releasing peptide Neuromedin-C / P07492* / gastrin releasing peptide*  / complex / reaction
 ENSMUSG00000025723 Nmb / Q9CR53 / Neuromedin-B Neuromedin-B-32 Neuromedin-B / P08949* / neuromedin B*  / complex / reaction






 

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