ENSMUSG00000026626


Mus musculus

Features
Gene ID: ENSMUSG00000026626
  
Biological name :Ppp2r5a
  
Synonyms : Ppp2r5a / protein phosphatase 2, regulatory subunit B, alpha / Q6PD03
  
Possible biological names infered from orthology : protein phosphatase 2 regulatory subunit Balpha / Q15172
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: H6
Gene start: 191351975
Gene end: 191403272
  
Corresponding Affymetrix probe sets: 10361104 (MoGene1.0st)   10510162 (MoGene1.0st)   10510197 (MoGene1.0st)   10518341 (MoGene1.0st)   1423911_at (Mouse Genome 430 2.0 Array)   1440189_at (Mouse Genome 430 2.0 Array)   1444036_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000141288
Ensembl peptide - ENSMUSP00000070726
NCBI entrez gene - 226849     See in Manteia.
MGI - MGI:2388479
RefSeq - NM_144880
RefSeq Peptide - NP_659129
swissprot - A0A0A6YVV9
swissprot - Q6PD03
Ensembl - ENSMUSG00000026626
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp2r5aENSDARG00000027017Danio rerio
 PPP2R5AENSGALG00000009828Gallus gallus
 Q15172ENSG00000066027Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q61151 / Ppp2r5e / protein phosphatase 2, regulatory subunit B, epsilon / Q16537* / protein phosphatase 2 regulatory subunit Bepsilon*ENSMUSG0000002105174
Q6PD28 / Ppp2r5b / protein phosphatase 2, regulatory subunit B, beta / Q15173* / protein phosphatase 2 regulatory subunit Bbeta*ENSMUSG0000002477770
Ppp2r5d / protein phosphatase 2, regulatory subunit B, delta / Q14738* / protein phosphatase 2 regulatory subunit Bdelta*ENSMUSG0000005940964
Q60996 / Ppp2r5c / protein phosphatase 2, regulatory subunit B, gamma / Q13362* / protein phosphatase 2 regulatory subunit Bgamma*ENSMUSG0000001784363


Protein motifs (from Interpro)
Interpro ID Name
 IPR002554  Protein phosphatase 2A, regulatory B subunit, B56
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0035307 positive regulation of protein dephosphorylation IEA
 biological_processGO:0043666 regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0090219 negative regulation of lipid kinase activity IEA
 biological_processGO:1903077 negative regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0000159 protein phosphatase type 2A complex IEA
 cellular_componentGO:0000775 chromosome, centromeric region IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0031430 M band IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019888 protein phosphatase regulator activity IEA
 molecular_functionGO:0019900 kinase binding IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000007564 Q76MZ3 / Ppp2r1a / protein phosphatase 2, regulatory subunit A, alpha / P30153* / protein phosphatase 2 scaffold subunit Aalpha*  / complex
 ENSMUSG00000009630 P62715 / Ppp2cb / Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform / P62714* / protein phosphatase 2 catalytic subunit beta*  / complex
 ENSMUSG00000006932 Ctnnb1 / Q02248 / Catenin beta-1 / P35222*  / reaction






 

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