ENSMUSG00000026786


Mus musculus

Features
Gene ID: ENSMUSG00000026786
  
Biological name :Apbb1ip
  
Synonyms : amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Apbb1ip / Q8R5A3
  
Possible biological names infered from orthology : amyloid beta precursor protein binding family B member 1 interacting protein / Q7Z5R6
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: A3
Gene start: 22774094
Gene end: 22875653
  
Corresponding Affymetrix probe sets: 10469695 (MoGene1.0st)   1425269_at (Mouse Genome 430 2.0 Array)   1443145_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014290
NCBI entrez gene - 54519     See in Manteia.
MGI - MGI:1861354
RefSeq - XM_011239139
RefSeq - NM_019456
RefSeq - XM_006498186
RefSeq - XM_006498187
RefSeq Peptide - NP_062329
swissprot - B1AYC9
swissprot - Q8R5A3
Ensembl - ENSMUSG00000026786
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 apbb1ipENSDARG00000016505Danio rerio
 APBB1IPENSGALG00000007579Gallus gallus
 Q7Z5R6ENSG00000077420Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Raph1 / Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 / Q70E73*ENSMUSG0000002601445
Grb10 / Q60760 / Growth factor receptor-bound protein 10 / Q13322*ENSMUSG0000002017619
Grb14 / Q9JLM9 / Growth factor receptor-bound protein 14 / Q14449*ENSMUSG0000002688819
Grb7 / Q03160 / Growth factor receptor-bound protein 7 / Q14451*ENSMUSG0000001931218


Protein motifs (from Interpro)
Interpro ID Name
 IPR000159  Ras-associating (RA) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002291 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0045785 positive regulation of cell adhesion IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0042101 T cell receptor complex IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
MAP2K and MAPK activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000021823 Vcl / Q64727 / vinculin / P18206*  / complex
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / complex / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / complex / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / complex / reaction
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000026193 Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*  / complex / reaction
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / complex / reaction
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex / reaction
 ENSMUSG00000001930 Vwf / Von Willebrand factor / P04275*  / complex / reaction






 

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