ENSMUSG00000028001


Mus musculus

Features
Gene ID: ENSMUSG00000028001
  
Biological name :Fga
  
Synonyms : E9PV24 / Fga / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain
  
Possible biological names infered from orthology : fibrinogen alpha chain / P02671
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E3
Gene start: 83026076
Gene end: 83033627
  
Corresponding Affymetrix probe sets: 10492748 (MoGene1.0st)   10492755 (MoGene1.0st)   1424279_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133117
Ensembl peptide - ENSMUSP00000029630
NCBI entrez gene - 14161     See in Manteia.
MGI - MGI:1316726
RefSeq - NM_001111048
RefSeq - NM_010196
RefSeq Peptide - NP_001104518
RefSeq Peptide - NP_034326
swissprot - E9PV24
Ensembl - ENSMUSG00000028001
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fgaENSDARG00000020741Danio rerio
 FGAENSGALG00000009266Gallus gallus
 FGAENSG00000171560Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tnc / Q80YX1 / tenascin C / P24821*ENSMUSG0000002836420
Tnxb / tenascin XB / P22105*ENSMUSG0000003332720
Tnr / Q8BYI9 / Tenascin-R / Q92752*ENSMUSG0000001582919
Tnn / Q80Z71 / Tenascin-N / Q9UQP3*ENSMUSG0000002672519
Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*ENSMUSG0000003383118
Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*ENSMUSG0000003386016
Fgl1 / fibrinogen like 1 / Q08830*ENSMUSG0000003159415
Fn1 / P11276 / Fibronectin Anastellin / P02751* / fibronectin 1*ENSMUSG0000002619314
Q9R182 / Angptl3 / Angiopoietin-related protein 3 ANGPTL3(17-224) / Q9Y5C1* / angiopoietin like 3*ENSMUSG0000002855314
Q9Z1P8 / Angptl4 / Angiopoietin-related protein 4 / Q9BY76* / angiopoietin like 4*ENSMUSG0000000228912


Protein motifs (from Interpro)
Interpro ID Name
 IPR002181  Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain
 IPR012290  Fibrinogen, alpha/beta/gamma chain, coiled coil domain
 IPR014715  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 2
 IPR014716  Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1
 IPR020837  Fibrinogen, conserved site
 IPR021996  Fibrinogen alpha C domain
 IPR036056  Fibrinogen-like, C-terminal
 IPR037579  Fibrinogen alpha chain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007160 cell-matrix adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007596 blood coagulation IMP
 biological_processGO:0007599 hemostasis IEA
 biological_processGO:0030168 platelet activation IEA
 biological_processGO:0031639 plasminogen activation IEA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0034622 cellular protein-containing complex assembly IEA
 biological_processGO:0042730 fibrinolysis IEA
 biological_processGO:0043152 induction of bacterial agglutination IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045907 positive regulation of vasoconstriction IEA
 biological_processGO:0045921 positive regulation of exocytosis IEA
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0051258 protein polymerization ISO
 biological_processGO:0051592 response to calcium ion IEA
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070527 platelet aggregation IEA
 biological_processGO:0072377 blood coagulation, common pathway IEA
 biological_processGO:0072378 blood coagulation, fibrin clot formation IEA
 biological_processGO:0090277 positive regulation of peptide hormone secretion IEA
 biological_processGO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005577 fibrinogen complex ISO
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005938 cell cortex IDA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0031091 platelet alpha granule IEA
 molecular_functionGO:0005102 signaling receptor binding ISO
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0030674 protein binding, bridging IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0050839 cell adhesion molecule binding IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin alphaIIb beta3 signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MAP2K and MAPK activation
Regulation of TLR by endogenous ligand
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1

 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Ndntm1Alb/Ndn+
Genetic Background: involves: 129S7/SvEvBrd

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0002551 abnormal blood coagulation "altered ability or inability of the blood to clot" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Vwftm1Wgr/Vwftm1Wgr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0002584 small ectoplacental cone 
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Thbdtm2Rdr/Thbdtm2Rdr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1

 MP:0003336 pancreatic cysts "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

 MP:0003633 abnormal nervous system physiology 
Show

Allelic Composition: Dnd1Ter/Dnd1+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0004014 abnormal uterine environment "anomaly or inability of the uterus to support embryonic development" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0004898 uterine hemorrhage "presence of bleeding in the uterus; often in response to failed pregnancy" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Plgtm1Jld/Plgtm1Jld
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * CF-1

 MP:0005245 hemarthrosis "bleeding into a joint space" [Pathology:ISBN 0-397-51047-0]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0005435 hemoperitoneum "blood in the peritoneal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87293]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0009549 impaired platelet aggregation "decrease in the ability of one platelet to one or more other platelets via adhesion molecules" [GO:0070527]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0010213 abnormal circulating fibrinogen level "deviation from the normal levels in the blood of a globulin that is converted into fibrin by the action of thrombin in the presence of ionized calcium to produce coagulation of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Vwftm1Wgr/Vwftm1Wgr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Fgatm1Jld/Fgatm1Jld,Thbdtm2Rdr/Thbdtm2Rdr
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0011514 skin hemorrhage "bleeding into the skin" [MGI:anna]
Show

Allelic Composition: Mapk14tm1Nbr/Mapk14tm1Nbr
Genetic Background: either: (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6) or (involves: 129S/SvEv * 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1)

Allelic Composition: Fgatm1Jld/Fgatm1Jld
Genetic Background: B6.129P2-Fgatm1Jld

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000020689 Itgb3 / O54890 / Integrin beta-3 / P05106* / AC068234.1* / integrin subunit beta 3*  / complex / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000070369 Itgad / Q3V0T4 / Integrin alpha-D / Q13349* / integrin subunit alpha D*  / complex / reaction
 ENSMUSG00000027249 F2 / P19221 / Prothrombin Activation peptide fragment 1 Activation peptide fragment 2 Thrombin light chain Thrombin heavy chain / P00734* / coagulation factor II, thrombin*  / reaction
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000032312 Csk / P41241 / Tyrosine-protein kinase CSK / P41240* / C-terminal Src kinase*  / complex / reaction
 ENSMUSG00000027540 Ptpn1 / P35821 / protein tyrosine phosphatase, non-receptor type 1 / P18031*  / reaction
 ENSMUSG00000026786 Q8R5A3 / Apbb1ip / amyloid beta (A4) precursor protein-binding, family B, member 1 interacting protein / Q7Z5R6* / amyloid beta precursor protein binding family B member 1 interacting protein*  / complex / reaction
 ENSMUSG00000017776 Crk / Q64010 / Adapter molecule crk / P46108* / CRK proto-oncogene, adaptor protein*  / complex / reaction
 ENSMUSG00000021823 Vcl / Q64727 / vinculin / P18206*  / complex
 ENSMUSG00000028465 Tln1 / P26039 / talin 1 / Q9Y490*  / complex / reaction
 ENSMUSG00000028001 Fga / E9PV24 / Fibrinogen alpha chain Fibrinopeptide A Fibrinogen alpha chain / P02671* / fibrinogen alpha chain*  / complex / reaction
 ENSMUSG00000052681 Rap1b / Q99JI6 / RAS related protein 1b / P61224* / RAP1B, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000021457 Syk / P48025 / spleen tyrosine kinase / P43405* / spleen associated tyrosine kinase*  / complex / reaction
 ENSMUSG00000033860 Fgg / Q8VCM7 / Fibrinogen gamma chain / P02679*  / complex / reaction
 ENSMUSG00000033831 Fgb / Q8K0E8 / Fibrinogen beta chain Fibrinopeptide B Fibrinogen beta chain / P02675* / fibrinogen beta chain*  / complex / reaction
 ENSMUSG00000068798 Rap1a / P62835 / RAS-related protein 1a / P62834* / RAP1A, member of RAS oncogene family*  / complex / reaction
 ENSMUSG00000034664 Itga2b / Q9QUM0 / integrin alpha 2b / P08514* / integrin subunit alpha 2b*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000031955 Bcar1 / Q61140 / Breast cancer anti-estrogen resistance protein 1 / P56945* / BCAR1, Cas family scaffolding protein*  / complex / reaction
 ENSMUSG00000030789 Itgax / Q9QXH4 / Integrin alpha-X / P20702* / integrin subunit alpha X*  / complex / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr