ENSMUSG00000027470


Mus musculus

Features
Gene ID: ENSMUSG00000027470
  
Biological name :Mylk2
  
Synonyms : Mylk2 / Myosin light chain kinase 2, skeletal/cardiac muscle / Q8VCR8
  
Possible biological names infered from orthology : myosin light chain kinase 2 / Q9H1R3
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H1
Gene start: 152911352
Gene end: 152923068
  
Corresponding Affymetrix probe sets: 10477206 (MoGene1.0st)   1427556_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000028970
NCBI entrez gene - 228785     See in Manteia.
MGI - MGI:2139434
RefSeq - NM_001081044
RefSeq - XM_011239481
RefSeq Peptide - NP_001074513
swissprot - Q8VCR8
Ensembl - ENSMUSG00000027470
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mylk2ENSDARG00000031698Danio rerio
 MYLK2ENSGALG00000006273Gallus gallus
 MYLK2ENSG00000101306Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mylk3 / Q3UIZ8 / Myosin light chain kinase 3 / Q32MK0*ENSMUSG0000003169839
Mylk / myosin light chain kinase / Q15746*ENSMUSG0000002283635
Mylk4 / myosin light chain kinase family member 4 / Q86YV6*ENSMUSG0000004495131
Speg / Q62407 / SPEG complex locus / Q15772*ENSMUSG0000002620723
Dapk1 / Q80YE7 / Death-associated protein kinase 1 / P53355*ENSMUSG0000002155920
Q8BG48 / Stk17b / Serine/threonine-protein kinase 17B / O94768* / serine/threonine kinase 17b*ENSMUSG0000002609419
Dapk3 / O54784 / Death-associated protein kinase 3 / O43293*ENSMUSG0000003497419
Dapk2 / Q8VDF3 / Death-associated protein kinase 2 / Q9UIK4*ENSMUSG0000003238018


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006941 striated muscle contraction IEA
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014816 skeletal muscle satellite cell differentiation IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IEA
 biological_processGO:0032971 regulation of muscle filament sliding IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0035914 skeletal muscle cell differentiation IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0055007 cardiac muscle cell differentiation NAS
 biological_processGO:0055008 cardiac muscle tissue morphogenesis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004687 myosin light chain kinase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002841 impaired skeletal muscle contractility "inability or reduced ability of the skeletal muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hhiptm1Amc/Hhiptm1Amc,Ptch1tm1Mps/Ptch1tm1Mps,Tg(Mt1-Ptch1)MT22Mps/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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