ENSMUSG00000031698


Mus musculus

Features
Gene ID: ENSMUSG00000031698
  
Biological name :Mylk3
  
Synonyms : Mylk3 / Myosin light chain kinase 3 / Q3UIZ8
  
Possible biological names infered from orthology : Q32MK0
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C3
Gene start: 85324303
Gene end: 85386345
  
Corresponding Affymetrix probe sets: 10580349 (MoGene1.0st)   1439101_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113960
Ensembl peptide - ENSMUSP00000123372
Ensembl peptide - ENSMUSP00000034133
Ensembl peptide - ENSMUSP00000113389
NCBI entrez gene - 213435     See in Manteia.
MGI - MGI:2443063
RefSeq - NM_175441
RefSeq - XM_006530825
RefSeq - NM_001297612
RefSeq Peptide - NP_001284541
RefSeq Peptide - NP_780650
swissprot - D3YZQ0
swissprot - Q3UIZ8
swissprot - D3Z630
Ensembl - ENSMUSG00000031698
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mylk3ENSDARG00000076348Danio rerio
 MYLK3ENSGALG00000004334Gallus gallus
 MYLK3ENSG00000140795Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mylk / myosin light chain kinase / Q15746*ENSMUSG0000002283630
Mylk2 / Q8VCR8 / Myosin light chain kinase 2, skeletal/cardiac muscle / Q9H1R3* / myosin light chain kinase 2*ENSMUSG0000002747030
Mylk4 / myosin light chain kinase family member 4 / Q86YV6*ENSMUSG0000004495128
Speg / Q62407 / SPEG complex locus / Q15772*ENSMUSG0000002620722
Dapk1 / Q80YE7 / Death-associated protein kinase 1 / P53355*ENSMUSG0000002155917
Dapk2 / Q8VDF3 / Death-associated protein kinase 2 / Q9UIK4*ENSMUSG0000003238016
Dapk3 / O54784 / Death-associated protein kinase 3 / O43293*ENSMUSG0000003497416
Q8BG48 / Stk17b / Serine/threonine-protein kinase 17B / O94768* / serine/threonine kinase 17b*ENSMUSG0000002609414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002528 regulation of vascular permeability involved in acute inflammatory response ISO
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0045214 sarcomere organization IDA
 biological_processGO:0048769 sarcomerogenesis IBA
 biological_processGO:0055003 cardiac myofibril assembly IBA
 biological_processGO:0060298 positive regulation of sarcomere organization IEA
 biological_processGO:0071347 cellular response to interleukin-1 ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004683 calmodulin-dependent protein kinase activity IDA
 molecular_functionGO:0004687 myosin light chain kinase activity IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
Show

Allelic Composition: Nkx3-1tm1Mms/Nkx3-1+,Ptentm1Rps/Pten+
Genetic Background: involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J

 MP:0000276 right ventricle hypertrophy "increased size of the right ventricle" [J:33629]
Show

Allelic Composition: Phgdhtm1.2Shfu/Phgdhtm1.2Shfu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Phgdhtm1.2Shfu/Phgdhtm1.2Shfu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Phgdhtm1.2Shfu/Phgdhtm1.2Shfu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0003915 increased left ventricle weight "greater than average weight of the left ventricle compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Phgdhtm1.2Shfu/Phgdhtm1.2Shfu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Phgdhtm1.2Shfu/Phgdhtm1.2Shfu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phgdhtm1.2Shfu/Phgdhtm1.2Shfu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Phgdhtm1.2Shfu/Phgdhtm1.2Shfu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Phgdhtm1.2Shfu/Phgdhtm1.2Shfu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010392 prolonged QRS complex duration "increase in the length of time of the largest-amplitude portion of the ECG, caused by currents generated when the ventricles depolarize prior to their contraction; prolongation of the QRS complex duration reflects slowed conduction in the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010508 abnormal heart electrocardiography waveform feature "any anomaly in the pattern of the graphic record of the integrated action currents of the cardiac cycle represented as changes in voltage; the prominent waves in the ECG correspond to specific conduction activity in areas of the heart and the timing and amplitude of ECG waveforms provide valuable information about heart rate and rhythm" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:20410536]
Show

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010632 cardiac muscle necrosis "pathological death of cardiomyocytes or a portion of the cardiac muscle tissue; usually due to irreversible damage" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1Jtst/Mylk3+
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0010724 thick interventricular septum "increased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Phgdhtm1.2Shfu/Phgdhtm1.2Shfu,Tg(GFAP-cre)25Mes/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0010754 abnormal heart left ventricle pressure "any anomaly in the pressure within the left cardiac ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

 MP:0012735 abnormal response to exercise "any anomaly in the physiological changes induced by controlled exercise" [MPD:Molly]
Show

Allelic Composition: Mylk3tm1.1Hkas/Mylk3tm1.1Hkas
Genetic Background: involves: 129 * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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