ENSMUSG00000027562


Mus musculus

Features
Gene ID: ENSMUSG00000027562
  
Biological name :Car2
  
Synonyms : Car2 / Mus musculus carbonic anhydrase 2 (Car2), transcript variant 2, mRNA. / P00920
  
Possible biological names infered from orthology : CA2 / carbonic anhydrase 2 / P00918
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A1
Gene start: 14886273
Gene end: 14900770
  
Corresponding Affymetrix probe sets: 10490923 (MoGene1.0st)   1448752_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029078
Ensembl peptide - ENSMUSP00000141876
NCBI entrez gene - 12349     See in Manteia.
MGI - MGI:88269
RefSeq - XM_006530050
RefSeq - NM_001357334
RefSeq - NM_009801
RefSeq Peptide - NP_001344263
RefSeq Peptide - NP_033931
swissprot - P00920
swissprot - A0A0A6YX78
Ensembl - ENSMUSG00000027562
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ca2ENSDARG00000014488Danio rerio
 cahzENSDARG00000011166Danio rerio
 CA2ENSGALG00000030781Gallus gallus
 CA2ENSG00000104267Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Car1 / P13634 / Carbonic anhydrase 1 / CA1* / P00915*ENSMUSG0000002755658
Car13 / Q9D6N1 / Carbonic anhydrase 13 / CA13* / Q8N1Q1*ENSMUSG0000002755557
Car3 / P16015 / Carbonic anhydrase 3 / CA3* / P07451*ENSMUSG0000002755957
Car7 / Q9ERQ8 / Carbonic anhydrase 7 / CA7* / P43166*ENSMUSG0000003188355
Car5b / Q9QZA0 / Carbonic anhydrase 5B, mitochondrial / CA5B* / Q9Y2D0* / carbonic anhydrase 5B*ENSMUSG0000003137353
Car5a / P23589 / Carbonic anhydrase 5A, mitochondrial / CA5A* / P35218* / carbonic anhydrase 5A*ENSMUSG0000002531750
Car8 / P28651 / Carbonic anhydrase-related protein / CA8* / P35219* / carbonic anhydrase 8*ENSMUSG0000004126142
Car12 / carbonic anhydrase 12 / CA12* / O43570*ENSMUSG0000003237336
Car14 / Q9WVT6 / Mus musculus carbonic anhydrase 14 (Car14), transcript variant 2, mRNA. / CA14* / Q9ULX7* / carbonic anhydrase 14*ENSMUSG0000003852636
Car9 / Q8VHB5 / Carbonic anhydrase 9 / CA9* / Q16790*ENSMUSG0000002846335
Car15 / Q99N23 / Carbonic anhydrase 15 ENSMUSG0000009023635
Car6 / P18761 / Carbonic anhydrase 6 / CA6* / P23280*ENSMUSG0000002897232
Car4 / Q64444 / Carbonic anhydrase 4 / CA4* / P22748*ENSMUSG0000000080530


Protein motifs (from Interpro)
Interpro ID Name
 IPR001148  Alpha carbonic anhydrase domain
 IPR018338  Carbonic anhydrase, alpha-class, conserved site
 IPR023561  Carbonic anhydrase, alpha-class
 IPR036398  Alpha carbonic anhydrase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0002009 morphogenesis of an epithelium IMP
 biological_processGO:0006730 one-carbon metabolic process IEA
 biological_processGO:0006885 regulation of pH IC
 biological_processGO:0009268 response to pH IEA
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010043 response to zinc ion IEA
 biological_processGO:0015670 carbon dioxide transport IMP
 biological_processGO:0032230 positive regulation of synaptic transmission, GABAergic IGI
 biological_processGO:0032849 positive regulation of cellular pH reduction IMP
 biological_processGO:0038166 angiotensin-activated signaling pathway IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0043627 response to estrogen IEA
 biological_processGO:0044070 regulation of anion transport IEA
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045780 positive regulation of bone resorption IEA
 biological_processGO:0046903 secretion IMP
 biological_processGO:0048545 response to steroid hormone IEA
 biological_processGO:0051453 regulation of intracellular pH IMP
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:2001150 positive regulation of dipeptide transmembrane transport IMP
 biological_processGO:2001225 regulation of chloride transport IMP
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0043209 myelin sheath IDA
 cellular_componentGO:0045177 apical part of cell IEA
 molecular_functionGO:0004064 arylesterase activity IEA
 molecular_functionGO:0004089 carbonate dehydratase activity ISO
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Erythrocytes take up carbon dioxide and release oxygen
Erythrocytes take up oxygen and release carbon dioxide
Reversible hydration of carbon dioxide


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000525 renal tubular acidosis "a clinical syndrome characterized by the inability to acidify urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19268]
Show

Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Car2tm1(KOMP)Vlcg/Car2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Prps2tm1a(KOMP)Wtsi/Y,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6N * SJL

 MP:0001663 abnormal digestive system physiology "altered function of the organ system that converts ingested food to nutrients and energy" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp5tm1Ask/Aqp5tm1Ask
Genetic Background: involves: C57BL/6J * CD-1

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prps2tm1a(KOMP)Wtsi/Y,Tg(IghMyc)22Bri/0
Genetic Background: involves: C57BL/6N * SJL

 MP:0003017 decreased circulating bicarbonate level "reduced concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Car2tm1(KOMP)Vlcg/Car2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0003027 abnormal blood pH regulation "anomaly in the function of the buffer systems of the blood in combination with the respiratory and renal systems that control the relative acidity or alkalinity of the blood, as measured by the concentration of the hydrogen ion" [RGD:Rat Genome Database submission, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Car2tm1(KOMP)Vlcg/Car2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0003271 abnormal duodenum morphology "malformation in the first division of the small intestine that extends from the pyloris to the junction with the jejunum " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0004008 abnormal GABA receptor currents "change in the measured amplitude or duration of response to stimulation of GABA receptors" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nmnat2Gt(EUCE0262a08)1.1Hmgu/Nmnat2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6J * SJL

 MP:0004119 hypokalemia "excessively low concentrations of potassium in the circulating blood; may be chronic or due to gastrointestinal and kidney depletion due to infection" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Car2tm1(KOMP)Vlcg/Car2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0004841 abnormal small intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the small intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9tm1Spas
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0005493 stomach epithelial hyperplasia 
Show

Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9tm1Spas
Genetic Background: involves: C57BL/6J * DBA/2J

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0006423 dilated rete testis "an expansion in the volume or area of the network of canals located at the termination of the straight tubules in the mediastinum testis, usually with an increase in contained fluid" [J:121125, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp5tm1Ask/Aqp5tm1Ask
Genetic Background: involves: C57BL/6J * CD-1

 MP:0009140 dilated efferent ductules of testis "an expansion in the volume or area of the lumen of the small seminal ducts that lead from the testis to the head of the epididymis, usually with an increase in contained fluid" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp5tm1Ask/Aqp5tm1Ask
Genetic Background: involves: C57BL/6J * CD-1

 MP:0009349 increased urine pH "increased urine alkalinity" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Car2tm1(KOMP)Vlcg/Car2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0010787 gastric cysts "abnormal membranous sacs in the wall of the stomach" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9tm1Spas
Genetic Background: involves: C57BL/6J * DBA/2J

 MP:0011403 pyelonephritis "a diffuse pyogenic infection of the pelvis and parenchyma of the kidney; an ascending urinary tract infection that has reached the pyelum or pelvis of the kidney usually resulting from noncontagious bacterial infection of the bladder" [MGI:anna]
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Allelic Composition: Car2tm1(KOMP)Vlcg/Car2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0011754 abnormal kidney collecting duct intercalated cell morphology "any structural anomaly of any of the functionally distinct subtypes of cells (alpha or beta) found on the kidney collecting duct epithelium that regulate acid-base homeostasis and play an important role in the kidney s response to acidosis and alkalosis; alpha-intercalated cells secrete acid whereas beta-intercalated cells secrete base; metabolic acidosis results in the conversion of beta- cells to alpha-intercalated cells giving the kidney a greater ability to secrete protons and return pH to the normal range" [MGI:anna]
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Allelic Composition: Car2tm1(KOMP)Vlcg/Car2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0012550 respiratory acidosis "acidosis caused by retention of and increased blood carbon dioxide concentration, often caused by decreased ventilation (hypoventilation); results in decreased blood pH unless kidneys compensate by retaining bicarbonate" [ISBN:0-683-40008-8]
Show

Allelic Composition: Bdnftm2(Ntf5)Jae/Bdnftm2(Ntf5)Jae
Genetic Background: involves: 129S4/SvJae

 MP:0012551 metabolic acidosis "decreased pH and bicarbonate concentration in tissues and/or body fluids caused when the body produces too much acid or when the kidneys are not removing enough acid from the body, as in diarrhea or in kidney disease" [ISBN:0-683-40008-8]
Show

Allelic Composition: Car2tm1(KOMP)Vlcg/Car2tm1(KOMP)Vlcg
Genetic Background: involves: C57BL/6 * C57BL/6NTac

 MP:0013567 gastric gland atrophy "acquired diminution of the size of any of the gastric glands, associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal change" [MGI:Anna]
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Allelic Composition: Car2n/Car2n,Car9tm1Spas/Car9+
Genetic Background: involves: C57BL/6J * DBA/2J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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