ENSMUSG00000027971


Mus musculus

Features
Gene ID: ENSMUSG00000027971
  
Biological name :Ndst4
  
Synonyms : Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 Heparan sulfate N-deacetylase 4 Heparan sulfate N-sulfotransferase 4 / Ndst4 / Q9EQW8
  
Possible biological names infered from orthology : N-deacetylase and N-sulfotransferase 4 / Q9H3R1
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: G1
Gene start: 125404076
Gene end: 125728899
  
Corresponding Affymetrix probe sets: 10495878 (MoGene1.0st)   1421318_at (Mouse Genome 430 2.0 Array)   1431452_at (Mouse Genome 430 2.0 Array)   1450195_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142414
Ensembl peptide - ENSMUSP00000120687
Ensembl peptide - ENSMUSP00000133341
Ensembl peptide - ENSMUSP00000133575
NCBI entrez gene - 64580     See in Manteia.
MGI - MGI:1932545
RefSeq - XM_017319683
RefSeq - NM_022565
RefSeq - XM_006501860
RefSeq - XM_011240189
RefSeq Peptide - NP_072087
swissprot - Q9EQW8
swissprot - G3UX70
swissprot - D3YWZ6
swissprot - A0A0G2JDL4
Ensembl - ENSMUSG00000027971
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ndst3ENSDARG00000041776Danio rerio
 NDST4ENSGALG00000012015Gallus gallus
 NDST4ENSG00000138653Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ndst3 / Q9EQH7 / N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 / O95803* / N-deacetylase and N-sulfotransferase 3*ENSMUSG0000002797780
Ndst1 / Q3UHN9 / Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 Heparan sulfate N-deacetylase 1 Heparan sulfate N-sulfotransferase 1 / P52848* / N-deacetylase and N-sulfotr...ENSMUSG0000005400871
Ndst2 / P52850 / N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 / P52849* / AC022400.6* / N-deacetylase and N-sulfotransferase 2* / bifunctional heparan sulfate N-deacetylase/N-s...ENSMUSG0000003930866
Q8BKN6 / Hs3st3a1 / Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 / Q9Y662* / HS3ST3B1* / heparan sulfate-glucosamine 3-sulfotransferase 3B1*ENSMUSG0000004775913
Q9QZS6 / Hs3st3b1 / Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 / Q9Y662* / heparan sulfate-glucosamine 3-sulfotransferase 3B1*ENSMUSG0000007040713
Hs3st4 / heparan sulfate-glucosamine 3-sulfotransferase 4 / Q9Y661*ENSMUSG0000007859112
Hs3st5 / Q8BSL4 / heparan sulfate (glucosamine) 3-O-sulfotransferase 5 / Q8IZT8* / heparan sulfate-glucosamine 3-sulfotransferase 5*ENSMUSG0000004449911
Hs3st6 / Q5GFD5 / Heparan sulfate glucosamine 3-O-sulfotransferase 6 / Q96QI5* / heparan sulfate-glucosamine 3-sulfotransferase 6*ENSMUSG0000003962810
Hs3st2 / Q673U1 / Heparan sulfate glucosamine 3-O-sulfotransferase 2 / Q9Y278* / heparan sulfate-glucosamine 3-sulfotransferase 2*ENSMUSG0000004632110
Hs3st1 / O35310 / Heparan sulfate glucosamine 3-O-sulfotransferase 1 / O14792* / heparan sulfate-glucosamine 3-sulfotransferase 1*ENSMUSG0000005102210


Protein motifs (from Interpro)
Interpro ID Name
 IPR000863  Sulfotransferase domain
 IPR021930  Heparan sulphate-N-deacetylase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR037359  Heparan sulfate sulfotransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0015012 heparan sulfate proteoglycan biosynthetic process IEA
 biological_processGO:0030210 heparin biosynthetic process IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008146 sulfotransferase activity IEA
 molecular_functionGO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019213 deacetylase activity IDA


Pathways (from Reactome)
Pathway description
HS-GAG biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Selenbp1tm1b(KOMP)Wtsi/Selenbp1+
Genetic Background: C57BL/6N-Selenbp1tm1b(KOMP)Wtsi/Mbp

 MP:0000495 abnormal colon morphology "malformation of the portion of the large intestine between the cecum and the rectum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Selenbp1tm1b(KOMP)Wtsi/Selenbp1+
Genetic Background: C57BL/6N-Selenbp1tm1b(KOMP)Wtsi/Mbp

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Selenbp1tm1b(KOMP)Wtsi/Selenbp1+
Genetic Background: C57BL/6N-Selenbp1tm1b(KOMP)Wtsi/Mbp

 MP:0014221 increased colon goblet cell number 
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Allelic Composition: Selenbp1tm1b(KOMP)Wtsi/Selenbp1+
Genetic Background: C57BL/6N-Selenbp1tm1b(KOMP)Wtsi/Mbp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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