ENSMUSG00000028068


Mus musculus

Features
Gene ID: ENSMUSG00000028068
  
Biological name :Iqgap3
  
Synonyms : Iqgap3 / IQ motif containing GTPase activating protein 3
  
Possible biological names infered from orthology : Q86VI3
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 88081971
Gene end: 88121048
  
Corresponding Affymetrix probe sets: 10493137 (MoGene1.0st)   1434850_at (Mouse Genome 430 2.0 Array)   1459405_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071715
Ensembl peptide - ENSMUSP00000142013
Ensembl peptide - ENSMUSP00000142035
NCBI entrez gene - 404710     See in Manteia.
MGI - MGI:3028642
RefSeq - XM_006501643
RefSeq - NM_001033484
RefSeq Peptide - NP_001028656
swissprot - A0A0A6YXJ2
swissprot - Q3UQP1
swissprot - F8VQ29
Ensembl - ENSMUSG00000028068
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 iqgap3ENSDARG00000098650Danio rerio
 IQGAP3ENSG00000183856Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Iqgap1 / Q9JKF1 / Ras GTPase-activating-like protein IQGAP1 / P46940* / IQ motif containing GTPase activating protein 1*ENSMUSG0000003053657
Iqgap2 / Q3UQ44 / Ras GTPase-activating-like protein IQGAP2 / Q13576* / IQ motif containing GTPase activating protein 2*ENSMUSG0000002167647


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR000593  RasGAP protein, C-terminal
 IPR001202  WW domain
 IPR001715  Calponin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036872  CH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IMP
 biological_processGO:0000187 activation of MAPK activity IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007265 Ras protein signal transduction IMP
 biological_processGO:0008361 regulation of cell size IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IMP
 biological_processGO:0071310 cellular response to organic substance IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0016328 lateral plasma membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding ISO
 molecular_functionGO:0017016 Ras GTPase binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IPI
 molecular_functionGO:0070856 myosin VI light chain binding ISO


Pathways (from Reactome)
Pathway description
RHO GTPases activate IQGAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000001175 Calm1 / P0DP28 / P0DP26 / P0DP27 / Calmodulin-1 / P0DP23*  / complex / reaction
 ENSMUSG00000062825 Actg1 / P63260 / Actin, cytoplasmic 2 Actin, cytoplasmic 2, N-terminally processed / P63261* / actin gamma 1*  / complex / reaction
 ENSMUSG00000028068 Iqgap3 / IQ motif containing GTPase activating protein 3 / Q86VI3*  / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000029580 Actb / P60710 / Actin, cytoplasmic 1 Actin, cytoplasmic 1, N-terminally processed / POTEJ* / P60709* / P0CG39* / actin beta* / POTE ankyrin domain family member J*  / complex / reaction






 

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