Manteia - Molecule gene

ENSMUSG00000028631

Mus musculus

Features

Gene ID:	ENSMUSG00000028631

Biological name :	Kcnq4

Synonyms :	Kcnq4 / Potassium voltage-gated channel subfamily KQT member 4 / Q9JK97

Possible biological names infered from orthology :	P56696 / potassium voltage-gated channel subfamily Q member 4

Species:	Mus musculus

Chr. number:	4
Strand:	-1
Band:	D2.2
Gene start:	120696138
Gene end:	120748612

Corresponding Affymetrix probe sets:	10515960 (MoGene1.0st) 1435721_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000030376 NCBI entrez gene - 60613 See in Manteia. MGI - MGI:1926803 RefSeq - XM_011240583 RefSeq - NM_001081142 RefSeq - XM_006503255 RefSeq - XM_011240582 RefSeq Peptide - NP_001074611 swissprot - Q9JK97 Ensembl - ENSMUSG00000028631

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
kcnq4	ENSDARG00000089490	Danio rerio
KCNQ4	ENSGALG00000038708	Gallus gallus
KCNQ4	ENSG00000117013	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Kcnq5 / Q9JK45 / Potassium voltage-gated channel subfamily KQT member 5 / Q9NR82* / potassium voltage-gated channel subfamily Q member 5*	ENSMUSG00000028033	58
Kcnq2 / potassium voltage-gated channel subfamily KQT member 2 isoform 13 / O43526* / potassium voltage-gated channel subfamily Q member 2*	ENSMUSG00000016346	52
Kcnq3 / Q8K3F6 / Potassium voltage-gated channel subfamily KQT member 3 / O43525* / potassium voltage-gated channel subfamily Q member 3*	ENSMUSG00000056258	45
Kcnq1 / P97414 / Potassium voltage-gated channel subfamily KQT member 1 / P51787* / potassium voltage-gated channel subfamily Q member 1*	ENSMUSG00000009545	33

Protein motifs (from Interpro)

Interpro ID	Name
IPR003937	Potassium channel, voltage dependent, KCNQ
IPR005821	Ion transport domain
IPR013821	Potassium channel, voltage dependent, KCNQ, C-terminal
IPR015573	Potassium channel, voltage dependent, KCNQ4
IPR028325	Voltage-gated potassium channel

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006811	ion transport	IEA
biological_process	GO:0006813	potassium ion transport	IMP
biological_process	GO:0007605	sensory perception of sound	IEA
biological_process	GO:0034765	regulation of ion transmembrane transport	IEA
biological_process	GO:0042472	inner ear morphogenesis	IMP
biological_process	GO:0055085	transmembrane transport	IEA
biological_process	GO:0071805	potassium ion transmembrane transport	IEA
cellular_component	GO:0005886	plasma membrane	IEA
cellular_component	GO:0008076	voltage-gated potassium channel complex	IEA
cellular_component	GO:0009925	basal plasma membrane	IEA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IBA
molecular_function	GO:0005216	ion channel activity	IEA
molecular_function	GO:0005244	voltage-gated ion channel activity	IEA
molecular_function	GO:0005249	voltage-gated potassium channel activity	IMP
molecular_function	GO:0005267	potassium channel activity	IEA

Pathways (from Reactome)

Pathway description

Voltage gated Potassium channels

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0004404	cochlear outer hair cell degeneration	"degeneration or loss of the columnar outer hair sensory cells of the organ of Corti" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chm^tm1.1Seab/Y,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Kcnq4^tm1.2Tjj/Kcnq4^tm1.2Tjj Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Kcnq4^tm1.2Tjj/Kcnq4⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0004434	abnormal cochlear outer hair cell physiology	"anomalies in processes pertinent to the function of cochlear OHCs which are known to enhance the performance of the cochlea, both qualitatively (increased selectivity) and quantitatively (increased sensitivity); in addition to the mechanoelectric transduction required for auditory sensation, OHCs also perform electromechanical transduction, whereby transmembrane voltage drives rapid changes in the length and stiffness of OHCs at audio frequencies in vitro (electromotility)" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq4^tm1.2Tjj/Kcnq4^tm1.2Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004737	absent distortion product otoacoustic emissions	"failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kcnq4^tm1.2Tjj/Kcnq4^tm1.2Tjj Genetic Background: involves: 129/Sv * C57BL/6
MP:0004740	sensorineural hearing loss	"a form of progressive hearing loss due to a lesion of the auditory division of cranial nerve VIII or the inner ear" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Chm^tm1.1Seab/Y,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Kcnq4^tm1.2Tjj/Kcnq4^tm1.2Tjj Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Kcnq4^tm1.2Tjj/Kcnq4⁺ Genetic Background: involves: 129/Sv * C57BL/6
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Chm^tm1.1Seab/Y,Tg(Six3-cre)69Frty/0 Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2 Allelic Composition: Kcnq4^tm1.2Tjj/Kcnq4^tm1.2Tjj Genetic Background: involves: 129/Sv * C57BL/6 Allelic Composition: Kcnq4^tm1.2Tjj/Kcnq4⁺ Genetic Background: involves: 129/Sv * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr