ENSMUSG00000028713


Mus musculus

Features
Gene ID: ENSMUSG00000028713
  
Biological name :Cyp4b1
  
Synonyms : Cyp4b1 / Cytochrome P450 4B1 / Q64462
  
Possible biological names infered from orthology : cytochrome P450 family 4 subfamily B member 1 / P13584
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: D1
Gene start: 115624725
Gene end: 115647723
  
Corresponding Affymetrix probe sets: 10515201 (MoGene1.0st)   1416194_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142279
Ensembl peptide - ENSMUSP00000099768
Ensembl peptide - ENSMUSP00000118323
NCBI entrez gene - 13120     See in Manteia.
MGI - MGI:103225
RefSeq - NM_007823
RefSeq Peptide - NP_031849
swissprot - Q64462
swissprot - A0A0A6YY50
swissprot - F6X6A4
swissprot - Q3TNA0
Ensembl - ENSMUSG00000028713
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyp4t8ENSDARG00000004964Danio rerio
 CYP4A22ENSGALG00000020688Gallus gallus
 CYP4B7ENSGALG00000010469Gallus gallus
 CYP4B1ENSG00000142973Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91WL5 / Cyp4a12a / Cytochrome P450 4A12A / Q02928* / Q5TCH4* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfamily A member 11*ENSMUSG0000006607153
Cyp4a12b / cytochrome P450, family 4, subfamily a, polypeptide 12B / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 sub...ENSMUSG0000007859753
O35728 / Cyp4a14 / Cytochrome P450 4A14 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfamily A member 11*ENSMUSG0000002871552
O88833 / Cyp4a10 / Cytochrome P450 4A10 / Q5TCH4* / Q02928* / CYP4A22* / CYP4A11* / cytochrome P450 family 4 subfamily A member 11* / cytochrome P450 family 4 subfamily A member 22*ENSMUSG0000006607252
Cyp4a29 / cytochrome P450, family 4, subfamily a, polypeptide 29 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000008313852
Cyp4a31 / cytochrome P450, family 4, subfamily a, polypeptide 31 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000002871251
Cyp4a32 / cytochrome P450, family 4, subfamily a, polypeptide 32 / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 subfa...ENSMUSG0000006392951
Cyp4a30b / cytochrome P450, family 4, subfamily a, polypeptide 30b / Q5TCH4* / Q02928* / CYP4A11* / CYP4A22* / cytochrome P450 family 4 subfamily A member 22* / cytochrome P450 family 4 sub...ENSMUSG0000008434650
Cyp4x1 / Q6A152 / Cytochrome P450 4X1 / Q8N118* / cytochrome P450 family 4 subfamily X member 1*ENSMUSG0000004715547
Q99N16 / Cyp4f18 / Leukotriene-B(4) omega-hydroxylase 2 / CYP4F3* / Q08477* / cytochrome P450 family 4 subfamily F member 3*ENSMUSG0000000348443
Cyp4f15 / cytochrome P450, family 4, subfamily f, polypeptide 15ENSMUSG0000007342443
Cyp4f40 / cytochrome P450, family 4, subfamily f, polypeptide 40ENSMUSG0000009070043
Cyp4f13 / cytochrome P450, family 4, subfamily f, polypeptide 13ENSMUSG0000002405542
Q9EP75 / Cyp4f14 / Mus musculus cytochrome P450, family 4, subfamily f, polypeptide 14 (Cyp4f14), transcript variant 6, mRNA.ENSMUSG0000002429242
Cyp4f16 / cytochrome P450, family 4, subfamily f, polypeptide 16ENSMUSG0000004844042
Cyp4f37 / cytochrome P450, family 4, subfamily f, polypeptide 37ENSMUSG0000006246442
Cyp4f39 / cytochrome P450, family 4, subfamily f, polypeptide 39 / Q6NT55* / CYP4F22* / cytochrome P450 family 4 subfamily F member 22*ENSMUSG0000006112641
Cyp4f17 / cytochrome P450, family 4, subfamily f, polypeptide 17ENSMUSG0000009158641
Q9DBW0 / Cyp4v3 / Cytochrome P450 4V2 / CYP4V2* / Q6ZWL3* / cytochrome P450 family 4 subfamily V member 2*ENSMUSG0000007905733


Protein motifs (from Interpro)
Interpro ID Name
 IPR001128  Cytochrome P450
 IPR002401  Cytochrome P450, E-class, group I
 IPR017972  Cytochrome P450, conserved site
 IPR036396  Cytochrome P450 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006725 cellular aromatic compound metabolic process IEA
 biological_processGO:0018879 biphenyl metabolic process IEA
 biological_processGO:0018917 fluorene metabolic process IEA
 biological_processGO:0042738 exogenous drug catabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031090 organelle membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0015643 toxic substance binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
 molecular_functionGO:0018585 fluorene oxygenase activity IEA
 molecular_functionGO:0020037 heme binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070330 aromatase activity IEA


Pathways (from Reactome)
Pathway description
Fatty acids
Eicosanoids
Synthesis of Leukotrienes (LT) and Eoxins (EX)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Cyp27b1tm1b(EUCOMM)Hmgu/Cyp27b1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cyp27b1tm1b(EUCOMM)Hmgu/Tcp

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cyp27b1tm1b(EUCOMM)Hmgu/Cyp27b1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cyp27b1tm1b(EUCOMM)Hmgu/Tcp

 MP:0004646 decreased cervical vertebrae number "reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Cyp27b1tm1b(EUCOMM)Hmgu/Cyp27b1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cyp27b1tm1b(EUCOMM)Hmgu/Tcp

 MP:0005566 decreased blood urea nitrogen level "low circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cyp27b1tm1b(EUCOMM)Hmgu/Cyp27b1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cyp27b1tm1b(EUCOMM)Hmgu/Tcp

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eml1heco/Eml1heco
Genetic Background: involves: C57BL/6 * NOR

 MP:0008935 decreased mean platelet volume "reduced average content of platelet cells over normal" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Cyp27b1tm1b(EUCOMM)Hmgu/Cyp27b1tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Cyp27b1tm1b(EUCOMM)Hmgu/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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