ENSMUSG00000028973


Mus musculus

Features
Gene ID: ENSMUSG00000028973
  
Biological name :Abcb8
  
Synonyms : Abcb8 / ATP-binding cassette, sub-family B (MDR/TAP), member 8 / Q9CXJ4
  
Possible biological names infered from orthology : ATP binding cassette subfamily B member 8 / Q9NUT2
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A3
Gene start: 24393663
Gene end: 24410054
  
Corresponding Affymetrix probe sets: 10520154 (MoGene1.0st)   1422015_a_at (Mouse Genome 430 2.0 Array)   1423713_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114767
Ensembl peptide - ENSMUSP00000143193
Ensembl peptide - ENSMUSP00000119791
Ensembl peptide - ENSMUSP00000072826
Ensembl peptide - ENSMUSP00000110729
NCBI entrez gene - 74610     See in Manteia.
MGI - MGI:1351667
RefSeq - XM_011249790
RefSeq - NM_029020
RefSeq - XM_006535812
RefSeq Peptide - NP_083296
swissprot - D3Z1J6
swissprot - Q9CXJ4
swissprot - F6ZFC5
swissprot - A0A0G2JFJ3
Ensembl - ENSMUSG00000028973
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcb8ENSDARG00000056672Danio rerio
 ABCB8ENSG00000197150Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcb10 / Q9JI39 / ATP-binding cassette, sub-family B (MDR/TAP), member 10 / Q9NRK6* / ATP binding cassette subfamily B member 10*ENSMUSG0000003197435
Abcb9 / Q9JJ59 / ATP-binding cassette, sub-family B (MDR/TAP), member 9 / Q9NP78* / ATP binding cassette subfamily B member 9*ENSMUSG0000002940830
Tap1 / P21958 / transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) / Q03518* / transporter 1, ATP binding cassette subfamily B member*ENSMUSG0000003732128
Tap2 / P36371 / transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) / Q03519* / AL669918.1* / transporter 2, ATP binding cassette subfamily B member*ENSMUSG0000002433927


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005743 mitochondrial inner membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA


Pathways (from Reactome)
Pathway description
Mitochondrial ABC transporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0003822 decreased left ventricle systolic pressure "decrease in the pressure in the left ventricle as the heart contracts and pumps blood into the arteries" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0004084 abnormal cardiac muscle relaxation "altered ability of the cardiac/heart muscle to lengthen following contractions, often measured by dP/dt min" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
Show

Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0010579 increased heart left ventricle size "greater than average size of the left ventricle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

 MP:0020367 increased heart iron level "increase in the amount of iron present in the heart tissue" [MGI:Anna]
Show

Allelic Composition: Abcb8tm1Hard/Abcb8tm1Hard,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: FVB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028973 Abcb8 / Q9CXJ4 / ATP-binding cassette, sub-family B (MDR/TAP), member 8 / Q9NUT2* / ATP binding cassette subfamily B member 8*  / complex






 

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