ENSMUSG00000029075


Mus musculus

Features
Gene ID: ENSMUSG00000029075
  
Biological name :Tnfrsf4
  
Synonyms : Tnfrsf4 / tumor necrosis factor receptor superfamily, member 4
  
Possible biological names infered from orthology : P43489 / TNF receptor superfamily member 4
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 156013843
Gene end: 156016612
  
Corresponding Affymetrix probe sets: 10511282 (MoGene1.0st)   1420351_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030952
NCBI entrez gene - 22163     See in Manteia.
MGI - MGI:104512
RefSeq - NM_011659
RefSeq - XM_006538724
RefSeq Peptide - NP_035789
swissprot - B1ASL3
Ensembl - ENSMUSG00000029075
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P43489ENSG00000186827Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR011641  Tyrosine-protein kinase ephrin type A/B receptor-like
 IPR020445  Tumour necrosis factor receptor 4
 IPR034022  Tumour necrosis factor receptor 4, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0042098 T cell proliferation IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
TNFs bind their physiological receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001192 scaly skin "skin covered with shedding scales or flakes" [J:65146]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001194 dermatitis "inflammation of the skin" [J:65146]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001200 thick skin "greater depth of skin " [J:47225]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001212 skin lesions "focal patches of inflammation on the skin" [J:30162]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001214 skin hyperplasia "increased cell number in the skin; usually results in thick skin" [J:47225]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0001242 hyperkeratosis "increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001828 abnormal T cell activation "anomaly in the process of producing effector T cells from naive T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Card11tm1.1Litt/Card11tm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gna11Mhdadsk7/Gna11Mhdadsk7
Genetic Background: involves: C3HeB/FeJ * C57BL/6J

 MP:0002405 respiratory system inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the respiratory system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Col3a1m1Lsmi/Col3a1+
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002656 abnormal keratinocyte differentiation "developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Rag2tm1Fwa/Rag2tm1Fwa,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0003413 hair follicle degeneration "a retrogressive impairment of function or destruction of the hair follicle" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94517]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Elavl1tm1.1Atas/Elavl1tm1.1Atas,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004803 increased susceptibility to autoimmune diabetes "greater likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic Background: involves: 129 * C57BL/6 * NOD * SJL

 MP:0004946 abnormal regulatory T cell physiology "any functional anomaly of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity; these may include T cells that express the CD8 transmembrane glycoprotein (CD8-positive T cells), those that express CD4 and CD25 (CD4-positive, CD25-positive regulatory T cells or "Tregs") and other T cell types that have suppressor function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Cd4tm1Nik/Cd4tm1Nik,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ

 MP:0004972 abnormal regulatory T cell number "deviation from the average count of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: B9d2/Tgfb1tm1Flv/B9d2+,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0004974 decreased regulatory T cell number "reduced number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0005015 increased T cell number "greater than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abca1tm1Jp/Abca1tm1Jp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Fyntm1Sor/Fyntm1Sor,Lcktm1Litt/Lcktm1.1Litt,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S7/SvEvBrd * 129X1/SvJ

Allelic Composition: Elavl1tm1.1Atas/Elavl1tm1.1Atas,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Ptentm1Hwu/Ptentm1Hwu,Tg(Scgb1a1-cre)1Tauc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Tnfrsf4tm1Mfb/Tnfrsf4tm1Mfb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005466 abnormal T helper 2 physiology "anomalous response of the subset of T helper cells that enhance humoral immunity and inhibit cell-mediated immune responses; these cells produce IL-4 and induce B cells to produce IgE and IgG1, while also supporting eosinophil and mast cell functions " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ncantm3Ref/Ncantm3Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
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Allelic Composition: B9d2/Tgfb1tm1Flv/B9d2+,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0008088 abnormal T-helper 1 cell differentiation "atypical production of or inability to produce the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008092 abnormal T-helper 2 cell differentiation "atypical production of or inability to produce the type of T-helper cell whose cytokine production promotes defense against extracellular parasites and humoral immune responses typical of allergy" [CL:0000546, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008177 increased germinal center B cell number "greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008482 decreased spleen germinal center number "reduced number of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008673 decreased interleukin-13 secretion "reduction in the production or release of a cytokine synthesized by T-cells that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-cells, and appears to play a role in regulating inflammatory and immune responses" [MESH:D12.644.276.374.465.513]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
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Allelic Composition: Pdia3Gt(RST613)Byg/Pdia3Gt(RST613)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B9d2/Tgfb1tm1Flv/B9d2+,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

 MP:0009932 skin fibrosis "invasion of fibrous connective tissue into the skin, often resulting from inflammation or injury" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0010186 increased T follicular helper cell number "greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Ptentm2.1Ppp/Ptentm2.1Ppp,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010187 decreased T follicular helper cell number "reduced number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]
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Allelic Composition: Pik3cdtm2.1Tnr/Pik3cdtm2.1Tnr,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
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Allelic Composition: B9d2/Tgfb1tm1Flv/B9d2+,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: B9d2/Tgfb1tm1Flv/Tgfb1tm2Flv,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129S6/SvEvTac * 129X1/SvJ

Allelic Composition: Elavl1tm1.1Atas/Elavl1tm1.1Atas,Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0011156 abnormal hypodermis fat layer morphology "any structural anomaly of the superficial portion of the subcutaneous tissue which is specialized for fat storage" [ISBN:0-683-40008-8]
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Allelic Composition: Pdpk1tm1.1Mlw/Pdpk1tm1.1Mlw,Tnfrsf4tm2(cre)Nik/Tnfrsf4+,Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic Background: involves: 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026700 P43488 / Tnfsf4 / Tumor necrosis factor ligand superfamily member 4 / P23510* / TNF superfamily member 4*  / complex / reaction
 ENSMUSG00000029075 Tnfrsf4 / tumor necrosis factor receptor superfamily, member 4 / P43489* / TNF receptor superfamily member 4*  / complex / reaction






 

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