ENSMUSG00000029322


Mus musculus

Features
Gene ID: ENSMUSG00000029322
  
Biological name :Plac8
  
Synonyms : Plac8 / Placenta-specific 8 protein / Q9JI48
  
Possible biological names infered from orthology : placenta specific 8 / Q9NZF1
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: E4
Gene start: 100553725
Gene end: 100572245
  
Corresponding Affymetrix probe sets: 10531724 (MoGene1.0st)   1451335_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031264
Ensembl peptide - ENSMUSP00000108531
Ensembl peptide - ENSMUSP00000108533
NCBI entrez gene - 231507     See in Manteia.
MGI - MGI:2445289
RefSeq - XM_017320851
RefSeq - NM_139198
RefSeq - XM_017320849
RefSeq - XM_017320850
RefSeq - XM_011249430
RefSeq Peptide - NP_631937
swissprot - Q9JI48
Ensembl - ENSMUSG00000029322
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plac8.1ENSDARG00000043729Danio rerio
 plac8.2ENSDARG00000094438Danio rerio
 ENSGALG00000011190Gallus gallus
 PLAC8L1ENSGALG00000020193Gallus gallus
 PLAC8ENSG00000145287Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnfn / Q6PCW6 / Cornifelin / Q9BYD5*ENSMUSG0000006365137
Q08EJ0 / Plac8l1 / PLAC8-like protein 1 / A1L4L8* / PLAC8 like 1*ENSMUSG0000005945530


Protein motifs (from Interpro)
Interpro ID Name
 IPR006461  PLAC8 motif-containing protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0009409 response to cold IMP
 biological_processGO:0040015 negative regulation of multicellular organism growth IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043066 negative regulation of apoptotic process IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0050873 brown fat cell differentiation IMP
 cellular_componentGO:0005634 nucleus IC
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Plac8tm1Bhk/Plac8tm1Bhk
Genetic Background: 129S/SvEv-Plac8tm1Bhk

 MP:0001260 increased body weight "greater than normal average weight " [J:33400]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Plac8tm1Bhk/Plac8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Plac8tm1Bhk/Plac8tm1Bhk
Genetic Background: 129S/SvEv-Plac8tm1Bhk

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Plac8tm1Bhk/Plac8tm1Bhk
Genetic Background: 129S/SvEv-Plac8tm1Bhk

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009124 increased brown fat cell lipid droplet size "increase in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Plac8tm1Bhk/Plac8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009137 decreased brown fat lipid droplet number "reduction in the number of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Plac8tm1Bhk/Plac8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0014142 increased body fat mass "increased physical bulk or volume of fat in the whole body" [MGI:csmith]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Plac8tm1Bhk/Plac8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0020520 whitened brown adipose tissue morphology "brown adipose tissue displays a morphology more closely resembling white adipose tissue (eg. unilocular lipid droplets, decreased lipid droplet numbers)" [MGI:mperry, PMID:24703692]
Show

Allelic Composition: Ighatm1Grh/Ighatm1Grh
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Plac8tm1Bhk/Plac8+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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