Manteia

ENSMUSG00000029364

Mus musculus

Features

Gene ID:	ENSMUSG00000029364

Biological name :	Wsb2

Synonyms :	O54929 / WD repeat and SOCS box-containing 2 / Wsb2

Possible biological names infered from orthology :	Q9NYS7

Species:	Mus musculus

Chr. number:	5
Strand:	1
Band:	F
Gene start:	117357304
Gene end:	117378601

Corresponding Affymetrix probe sets:	10524882 (MoGene1.0st) 1421846_at (Mouse Genome 430 2.0 Array) 1421847_at (Mouse Genome 430 2.0 Array) 1438129_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000107590 Ensembl peptide - ENSMUSP00000031309 NCBI entrez gene - 59043 See in Manteia. MGI - MGI:2144041 RefSeq - NM_021539 RefSeq Peptide - NP_067514 swissprot - E9Q8J9 swissprot - O54929 Ensembl - ENSMUSG00000029364

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
wsb2	ENSDARG00000058608	Danio rerio
WSB2	ENSGALG00000008151	Gallus gallus
WSB2	ENSG00000176871	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Wsb1 / O54927 / WD repeat and SOCS box-containing 1 / Q9Y6I7*	ENSMUSG00000017677	47
Ciao1 / Q99KN2 / Probable cytosolic iron-sulfur protein assembly protein CIAO1 / O76071* / cytosolic iron-sulfur assembly component 1*	ENSMUSG00000003662	20

Protein motifs (from Interpro)

Interpro ID	Name
IPR001496	SOCS box domain
IPR001680	WD40 repeat
IPR011042	Six-bladed beta-propeller, TolB-like
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR017986	WD40-repeat-containing domain
IPR019775	WD40 repeat, conserved site
IPR020472	G-protein beta WD-40 repeat
IPR036036	SOCS box-like domain superfamily
IPR036322	WD40-repeat-containing domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0008150	biological_process	ND
biological_process	GO:0016567	protein ubiquitination	IEA
biological_process	GO:0035556	intracellular signal transduction	IEA
cellular_component	GO:0005575	cellular_component	ND
cellular_component	GO:0005622	intracellular	IEA
molecular_function	GO:0003674	molecular_function	ND
molecular_function	GO:0005515	protein binding	IEA

Pathways (from Reactome)

Pathway description

Neddylation

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000565	oligodactyly	"congenital condition in which some digits or parts of digits are missing" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0001399	hyperactivity	"general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0001925	male infertility	"inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0002100	abnormal tooth morphology	"atypical size, shape or hard tissue structure of the teeth " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0002757	reduced vertical activity	"lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0002792	abnormal retinal vascularization	"malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0003382	straub tail	"condition in which an animal carries its tail in an erect (vertical or nearly vertical) position; often seen upon opioid and other drug treatment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0005333	decreased heart rate	"fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0010052	increased grip strength	"greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0010068	decreased red blood cell distribution width	"lower than normal coefficient of variance (reference range) of the red blood cell volume for an organism" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", NCI:C64800 "NCI Thesaurus (Code C64800)"]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0010097	abnormal retinal blood vessel morphology	"any structural anomaly of the blood vessels supplying the retina" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0010379	decreased respiratory quotient	"reduction in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0011940	decreased food intake	"reduction in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H
MP:0011965	decreased total retina thickness	"decreased width of the retina through the center plane" [MGI:csmith]	Show Allelic Composition: Nsd3^{tm1b(EUCOMM)Hmgu}/Nsd3^{tm1b(EUCOMM)Hmgu} Genetic Background: C57BL/6N-Nsd3^{tm1b(EUCOMM)Hmgu}/H

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2025 contact: otassy@igbmc.fr