ENSMUSG00000029510


Mus musculus

Features
Gene ID: ENSMUSG00000029510
  
Biological name :Gpc2
  
Synonyms : glypican 2 (cerebroglycan) / Gpc2 / Q8BKV1
  
Possible biological names infered from orthology : glypican 2 / Q8N158
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 138273655
Gene end: 138280005
  
Corresponding Affymetrix probe sets: 10535021 (MoGene1.0st)   1429293_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000014089
Ensembl peptide - ENSMUSP00000124459
Ensembl peptide - ENSMUSP00000137879
NCBI entrez gene - 71951     See in Manteia.
MGI - MGI:1919201
RefSeq - XM_017321104
RefSeq - NM_172412
RefSeq - XM_006504621
RefSeq - XM_006504623
RefSeq - XM_006504624
RefSeq Peptide - NP_766000
swissprot - M0QWK4
swissprot - F8WHY9
swissprot - Q8BKV1
Ensembl - ENSMUSG00000029510
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpc2ENSDARG00000104217Danio rerio
 GPC2ENSG00000213420Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm43720 / GPC2* / Q8N158* / glypican 2*ENSMUSG0000010624743
Gpc6 / Q9R087 / glypican 6 / Q9Y625*ENSMUSG0000005857139
Gpc4 / P51655 / glypican 4 / O75487*ENSMUSG0000003111937
Gpc1 / Q9QZF2 / glypican 1 / P35052*ENSMUSG0000003422034
Gpc5 / Q8CAL5 / glypican 5 / P78333*ENSMUSG0000002211222
Gpc3 / Q8CFZ4 / glypican 3 / P51654*ENSMUSG0000005565320


Protein motifs (from Interpro)
Interpro ID Name
 IPR001863  Glypican
 IPR019803  Glypican, conserved site
 IPR031181  Glypican-2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009966 regulation of signal transduction IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Col1a1tm1(tetO-Yod1*)Hpl/Col1a1tm1(tetO-Yod1*)Hpl,Gt(ROSA)26Sortm1(rtTA*M2)Jae/Gt(ROSA)26Sortm1(rtTA*M2)Jae,Tap1tm1Arp/Tap1tm1Arp
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002768 small adrenal glands "reduced size of endocrine glands located above the kidneys responsible for hormone and epinephrine secretion" [J:78062]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0002989 small kidney "reduced physical bulk one or both of the organs responsible for urine secretion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Golga3tm1b(EUCOMM)Hmgu/Golga3tm1b(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Golga3tm1b(EUCOMM)Hmgu/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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