ENSMUSG00000058571


Mus musculus

Features
Gene ID: ENSMUSG00000058571
  
Biological name :Gpc6
  
Synonyms : glypican 6 / Gpc6 / Q9R087
  
Possible biological names infered from orthology : Q9Y625
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: E4
Gene start: 116925315
Gene end: 117976544
  
Corresponding Affymetrix probe sets: 10416974 (MoGene1.0st)   1419688_at (Mouse Genome 430 2.0 Array)   1419689_at (Mouse Genome 430 2.0 Array)   1428774_at (Mouse Genome 430 2.0 Array)   1437417_s_at (Mouse Genome 430 2.0 Array)   1441438_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077893
Ensembl peptide - ENSMUSP00000085835
Ensembl peptide - ENSMUSP00000120362
NCBI entrez gene - 23888     See in Manteia.
MGI - MGI:1346322
RefSeq - NM_011821
RefSeq - NM_001079844
RefSeq Peptide - NP_001073313
RefSeq Peptide - NP_035951
swissprot - Q3V1C9
swissprot - Q8R3X6
swissprot - Q9R087
Ensembl - ENSMUSG00000058571
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gpc6aENSDARG00000103156Danio rerio
 gpc6bENSDARG00000104219Danio rerio
 GPC6ENSGALG00000016900Gallus gallus
 GPC6ENSG00000183098Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gpc4 / P51655 / glypican 4 / O75487*ENSMUSG0000003111964
Gpc1 / Q9QZF2 / glypican 1 / P35052*ENSMUSG0000003422045
Gpc2 / Q8BKV1 / glypican 2 (cerebroglycan) / Q8N158* / glypican 2*ENSMUSG0000002951040
Gpc5 / Q8CAL5 / glypican 5 / P78333*ENSMUSG0000002211224
Gpc3 / Q8CFZ4 / glypican 3 / P51654*ENSMUSG0000005565323
Gm43720 / GPC2* / Q8N158* / glypican 2*ENSMUSG0000010624720


Protein motifs (from Interpro)
Interpro ID Name
 IPR001863  Glypican
 IPR019803  Glypican, conserved site
 IPR031183  Glypican-6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009966 regulation of signal transduction IEA
 biological_processGO:0016477 cell migration ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031225 anchored component of membrane IEA
 cellular_componentGO:0046658 anchored component of plasma membrane IEA
 molecular_functionGO:0043395 heparan sulfate proteoglycan binding IEA


Pathways (from Reactome)
Pathway description
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG degradation
Retinoid metabolism and transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

 MP:0002765 short fibula "reduced length of the lateral and smaller of bone of the lower leg" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:12736]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

 MP:0003109 short femur "reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

Allelic Composition: Gpc6tm1Lex/Gpc6+,Ihhtm1Amc/Ihh+
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6N

Allelic Composition: Gpc6tm1Lex/Gpc6tm1Lex,Ihhtm1Amc/Ihhtm1Amc
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6N

 MP:0003662 abnormal proliferative zone "germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

Allelic Composition: Gpc6tm1Lex/Gpc6tm1Lex
Genetic Background: B6N.129S5(B6)-Gpc6tm1Lex/Mmucd

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

 MP:0004214 abnormal long bone diaphysis morphology "any structural anomaly of the main or mid section (shaft) of a long bone" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpc6tm1Lex/Gpc6tm1Lex
Genetic Background: B6N.129S5(B6)-Gpc6tm1Lex/Mmucd

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

Allelic Composition: Gpc6tm1Lex/Gpc6tm1Lex
Genetic Background: B6N.129S5(B6)-Gpc6tm1Lex/Mmucd

 MP:0004872 absent nasal septum "absence of the structure that separates the two nasal cavities" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpc6tm1Lex/Gpc6tm1Lex
Genetic Background: B6N.129S5(B6)-Gpc6tm1Lex/Mmucd

 MP:0005352 small skull "less than the normal size of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Capzbtm1c(EUCOMM)Wtsi/Capzbtm1c(EUCOMM)Wtsi,Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+,Tg(Atoh1-cre)1Bfri/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6N * CBA * SJL

 MP:0009431 decreased fetal weight "reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gpc6tm1Lex/Gpc6tm1Lex
Genetic Background: B6N.129S5(B6)-Gpc6tm1Lex/Mmucd

Allelic Composition: Gpc6tm1Lex/Gpc6+,Ihhtm1Amc/Ihh+
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6N

Allelic Composition: Gpc6tm1Lex/Gpc6tm1Lex,Ihhtm1Amc/Ihhtm1Amc
Genetic Background: involves: 129S1/Sv * 129S5/SvEvBrd * 129X1/SvJ * C57BL/6N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gpc6tm1Lex/Gpc6tm1Lex
Genetic Background: B6N.129S5(B6)-Gpc6tm1Lex/Mmucd

 MP:0014101 decreased chondrocyte proliferation "decreased amount of multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population" [GO:0035988]
Show

Allelic Composition: Gpc6tm1Lex/Gpc6tm1Lex
Genetic Background: B6N.129S5(B6)-Gpc6tm1Lex/Mmucd

 MP:0030190 small snout "decreased size of the anterior facial part of the face or muzzle containing the oral and nasal regions" [MGI:anna]
Show

Allelic Composition: Gpc6tm1Lex/Gpc6tm1Lex
Genetic Background: B6N.129S5(B6)-Gpc6tm1Lex/Mmucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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